BACKGROUND & AIMS: Much is known about the genes and mutations that cause colorectal
cancer (CRC), yet only a few have been associated with CRC metastasis. We performed …

In the development of the mammalian intestine, Notch and Wnt/β-catenin signals control stem
cell maintenance and their differentiation into absorptive and secretory cells. Mechanisms …

We show that activation of Wnt/β‐catenin and attenuation of Bmp signals, by combined gain‐
and loss‐of‐function mutations of β‐catenin and Bmpr1a, respectively, results in rapidly …

Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal
cancer stem cells. Here we identify the histone methyltransferase Mll1 as a regulator of …

Specified intestinal epithelial cells reprogram and contribute to the regeneration and renewal
of the epithelium upon injury. Mutations that deregulate such renewal processes may …

Differentiation and lineage specification are controlled by cooperation of growth factor
signalling. The involvement of epigenetic regulators in lineage specification remains largely …

MLL3 1 Ch Berlin4 1 M 32 parotid 3 n (n-high)- high 2 Ch Berlin 2 M 55 parotid 2 n (n-med)-
med 3 Ch Berlin 3 F 64 parotid 3 n (n-med)- med 4 Ch Berlin 4 F 71 parotid 3 n (n-high)- …

Two papers published in Science Signaling reveal extensive crosstalk between Wnt/β-catenin
and mitogen-activated protein kinase (MAPK) signaling in cancer. Although both studies …

… We thank Carmen Birchmeier for helpful discussions and valuable comments on the manuscript,
Frauke Kosel for excellent technical assistance and Marta Rosario for critical reading of …

… We thank Juliette Bergemann and Daniel Stepczynski from the MDC animal facility, and
Frauke Kosel for technical assistance (MDC). The work was supported by funds of the “Berliner …