Cateslytin, a positively charged (5+) arginine-rich antimicrobial peptide (bCgA,
RSMRLSFRARGYGFR), was chemically synthesized and studied against membranes that mimic …

RAS is a signaling protein associated with the cell membrane that is mutated in up to 30%
of human cancers. RAS signaling has been proposed to be regulated by dynamic …

We investigate the mode of action of Cateslytin, an antimicrobial peptide, on zwitterionic
biomembranes by performing numerical simulations and electrophysiological measurements on …

The gene encoding the GTPase KRAS is frequently mutated in pancreatic, lung, and colorectal
cancers. The KRAS fraction in the plasma membrane (PM) correlates with activation of …

Plasma membrane (PM) curvature defines cell shape and intracellular organelle morphologies
and is a fundamental cell property. Growth/proliferation is more stimulated in flatter cells …

Membrane interacting peptides are reviewed in terms of structure and mode of action on
lipid membranes. Helical, β-stranded, peptides containing both helices and strands, cyclic, …

The specificity of the stress‐produced antimicrobial peptide cateslytin to fungi membranes
has been investigated using complex membrane models made of zwitterionic and negatively …

… Author links open overlay panel Frantz L. Jean-Francois 1 2 , Jian Dai 3 4 , Lu Yu 5 , Alissa
Myrick 6 , Eric Rubin 6 , Piotr G. Fajer 1 4 , Likai Song 1 , Huan-Xiang Zhou 3 4 , Timothy A. …

Cateslytin (bCGA 344 RSMRLSFRARGYGFR 358 ), a five positively charged 15 amino-acid
residues arginine-rich antimicrobial peptide, was synthesized using a very efficient …

Fragment‐based drug discovery (FBDD) is widely practiced in the pharmaceutical industry,
and has also been increasingly adopted in academia. A FBDD approach takes advantage of …