All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family (p38α,
p38β, p38γ and p38δ) are activated by dual phosphorylation in the TGY motif in the …

The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce
and integrate extracellular stimuli into coordinated cellular response. Here, we report the …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset
autosomal dominant Parkinson's disease. LRRK2 is highly expressed in immune cells and …

The G2019S leucine rich repeat kinase 2 (LRRK2) mutation is the most common genetic
cause of Parkinson's disease (PD), clinically and pathologically indistinguishable from …

The Ca 2+ ‐ATPase of skeletal muscle sarcoplasmic reticulum (SERCA), an integral
membrane protein, becomes irreversibly inactivated in vitro by the addition of a single bolus of …

ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation,
is activated selectively by dual phosphorylation in the TEY motif by MAPK kinase 5 (…

The creation of translation-competent mRNA is dependent on RNA polymerase II transcripts
being modified by addition of the 7-methylguanosine (m7G) cap. The factors that mediate …

CMTR1 contributes to mRNA cap formation by methylating the first transcribed nucleotide
ribose at the O-2 position. mRNA cap O-2 methylation has roles in mRNA stabilisation and …

mRNA is modified co‐transcriptionally at the 5′ end by the addition of an inverted guanosine
cap structure which can be methylated at several positions. The mRNA cap recruits …

Activation of p38γ modulates the integrity of the complex formed by the human discs large
protein (hDlg) with cytoskeletal proteins, which is important for cell adaptation to changes in …