User profiles for Fok-Moon Lum

Fok Moon Lum

Investigator
Verified email at idlabs.a-star.edu.sg
Cited by 2758

[HTML][HTML] Monkeypox: disease epidemiology, host immunity and clinical interventions

FM Lum, A Torres-Ruesta, MZ Tay, RTP Lin… - Nature Reviews …, 2022 - nature.com
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted
to the African continent, with only a handful of sporadic cases in other parts of the world. …

Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics

JB Steinman, FM Lum, PPK Ho… - Proceedings of the …, 2020 - National Acad Sciences
The reduced development of COVID-19 for children compared to adults provides some
tantalizing clues on the pathogenesis and transmissibility of this pandemic virus. First, ACE2, the …

Cellular and molecular mechanisms of chikungunya pathogenesis

FM Lum, LFP Ng - Antiviral research, 2015 - Elsevier
Chikungunya virus (CHIKV) is an arthropod-borne virus that causes chikungunya fever, a
disease characterized by the onset of fever and rashes, with arthralgia as its hallmark symptom…

A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice

TH Teo, FM Lum, C Claser, V Lulla, A Lulla… - The Journal of …, 2013 - journals.aai.org
Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating
arthralgia in humans. Injury to the joint is believed to occur because of viral and host immune-…

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

YW Kam, FM Lum, TH Teo, WWL Lee… - EMBO molecular …, 2012 - embopress.org
Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic
outbreaks with serious economic and social impact. The immune mechanisms, which …

[HTML][HTML] Viperin restricts chikungunya virus replication and pathology

…, SS Foo, D Simamarta, FM Lum… - The Journal of …, 2012 - Am Soc Clin Investig
Chikungunya virus (CHIKV) is a mosquito-borne arthralgia arbovirus that is reemergent in
sub-Saharan Africa and Southeast Asia. CHIKV infection has been shown to be self-limiting, …

[HTML][HTML] An essential role of antibodies in the control of Chikungunya virus infection

FM Lum, TH Teo, WWL Lee, YW Kam… - The Journal of …, 2013 - journals.aai.org
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in
intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV …

Zika virus infects human fetal brain microglia and induces inflammation

FM Lum, DKS Low, Y Fan, JJL Tan… - Clinical Infectious …, 2017 - academic.oup.com
Background. The unprecedented reemergence of Zika virus (ZIKV) has startled the world with
reports of increased microcephaly in Brazil. ZIKV can infect human neural progenitors and …

[HTML][HTML] Paradoxical effect of chloroquine treatment in enhancing chikungunya virus infection

…, SD Thiberville, L Dupuis-Maguiraga, FM Lum… - Viruses, 2018 - mdpi.com
Since 2005, Chikungunya virus (CHIKV) re-emerged and caused numerous outbreaks in
the world, and finally, was introduced into the Americas in 2013. The lack of CHIKV-specific …

Caribbean and La Reunion chikungunya virus isolates differ in their capacity to induce proinflammatory Th1 and NK cell responses and acute joint pathology

TH Teo, Z Her, JJL Tan, FM Lum, WWL Lee… - Journal of …, 2015 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a mosquito-borne arthralgic alphavirus that has garnered
international attention as an important emerging pathogen since 2005. More recently, it invaded …