Intrinsic and adaptive resistance hampers the success of antiangiogenic therapies (AAT),
especially in breast cancer where this treatment modality has proven largely ineffective. …

BACKGROUND & AIMS: Chronic pancreatitis is characterized by alternating phases of acute
inflammation and quiescent disease. Involvement of T-cell responses has been suggested, …

Despite enormous efforts to improve therapeutic options, pancreatic cancer remains a fatal
disease and is expected to become the second leading cause of cancer-related deaths in the …

Anti-angiogenic therapies were approved for different cancers. However, significant primary
and secondary resistance hampers efficacy in several tumor types including breast cancer. …

Although inhibitors of bromodomain and extra terminal domain (BET) proteins show
promising clinical activity in different hematologic malignancies, a systematic analysis of the …

BCR-ABL negative myeloproliferative neoplasms (MPNs) consist of essential thrombocythemia,
polycythemia vera, and myelofibrosis. The majority of patients harbor the JAK2-…

Despite significant efforts in the last years to improve therapeutic options, pancreatic cancer
remains a fatal disease and is expected to become the second leading cause of cancer-…

Efficacy of anti-angiogenic drugs is hampered by hypoxia-induced resistance. Because
cyclooxygenase-2 (Cox-2) is upregulated in hypoxic conditions we analyzed mRNA expression …

Significance: Targeted therapies have revolutionized the treatment of cancer. However,
efficacy of anti-angiogenic therapies is limited due to significant resistance. Recent studies …

Background/significance: Bromodomain and extra terminal domain (BET) proteins have
been shown to be critical for maintaining the function of leukemia stem cells. Although BET-…