Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth
FC Brownfoot, DI Gagliardi, E Bain… - Cochrane Database …, 2013 - cochranelibrary.com
Background Despite the widespread use of antenatal corticosteroids to prevent respiratory
distress syndrome in preterm infants, there is currently no consensus as to the type of …
distress syndrome in preterm infants, there is currently no consensus as to the type of …
Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction
… Author links open overlay panel Fiona C. Brownfoot MBBS a , Roxanne Hastie BBiomed
Sc a , Natalie J. Hannan B Sci, PhD a , Ping Cannon B Sci a , Laura Tuohey BSci a , Laura J. …
Sc a , Natalie J. Hannan B Sci, PhD a , Ping Cannon B Sci a , Laura Tuohey BSci a , Laura J. …
Effects of pravastatin on human placenta, endothelium, and women with severe preeclampsia
Preeclampsia is a major pregnancy complication where excess placental release of soluble
fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin causes maternal endothelial and …
fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin causes maternal endothelial and …
[HTML][HTML] Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical …
Background Preeclampsia is associated with the placental release of soluble fms-like
tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause …
tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause …
[HTML][HTML] Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction–implications as a …
NJ Hannan, FC Brownfoot, P Cannon, M Deo… - Scientific reports, 2017 - nature.com
Preeclampsia is a disease of pregnancy associated with placental oxidative stress,
inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These …
inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These …
EGFR (epidermal growth factor receptor) signaling and the mitochondria regulate sFlt-1 (soluble FMS-like tyrosine kinase-1) secretion
Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial
dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1 (soluble FMS-like …
dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1 (soluble FMS-like …
[HTML][HTML] Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction
FC Brownfoot, NJ Hannan, P Cannon, V Nguyen… - …, 2019 - thelancet.com
Background Preeclampsia is a major complication of pregnancy with no medical treatment.
It is associated with placental oxidative stress, hypoxia and inflammation leading to soluble …
It is associated with placental oxidative stress, hypoxia and inflammation leading to soluble …
A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol
…, BW Mol, D Hall, R Hiscock, FC Brownfoot… - BMJ open, 2019 - bmjopen.bmj.com
Introduction Pre-eclampsia is a major complication of pregnancy, globally responsible for
60 000 maternal deaths per year, and far more fetal losses. There is no definitive treatment …
60 000 maternal deaths per year, and far more fetal losses. There is no definitive treatment …
[HTML][HTML] Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction–implications for treating …
TJ Kaitu'u-Lino, FC Brownfoot, S Beard, P Cannon… - PLoS …, 2018 - journals.plos.org
Introduction The discovery of new treatments that prevent or treat preeclampsia would be a
major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble …
major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble …
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health
…, BR Fato, J Tu'uhevaha, FC Brownfoot… - Life science …, 2022 - life-science-alliance.org
Preeclampsia affects ∼2–8% of pregnancies worldwide. It is associated with increased long-term
maternal cardiovascular disease risk. This study assesses the effect of the …
maternal cardiovascular disease risk. This study assesses the effect of the …