User profiles for Fabio Ticconi

Fabio Ticconi

Uniklinik RWTH Aachen
Verified email at rwth-aachen.de
Cited by 168

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

…, R Weiskirchen, F Ticconi… - Proceedings of the …, 2018 - National Acad Sciences
E-type cyclins E1 (CcnE1) and E2 (CcnE2) are regulatory subunits of cyclin-dependent kinase
2 (Cdk2) and thought to control the transition of quiescent cells into the cell cycle. Initial …

Resident regulatory T cells reflect the immune history of individual lymph nodes

A Kaminski, FT Hager, L Kopplin, F Ticconi… - Science …, 2023 - science.org
Regulatory T cells (T regs ) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. T regs in …

[HTML][HTML] LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma

R Pellegrino, M Castoldi, F Ticconi, B Skawran… - Cells, 2022 - mdpi.com
Genomic and epigenomic studies revealed dysregulation of long non-coding RNAs in many
cancer entities, including liver cancer. We identified an epigenetic mechanism leading to …

[PDF][PDF] Cognate recognition of microbial antigens defines constricted CD4+ T cell receptor repertoires in the inflamed colon

M Muschaweck, L Kopplin, F Ticconi, A Schippers… - Immunity, 2021 - cell.com
Key aspects of intestinal T cells, including their antigen specificity and their selection by the
microbiota and other intestinal antigens, as well as the contribution of individual T cell clones …

Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

T Božić, J Frobel, A Raic, F Ticconi… - Life science …, 2018 - life-science-alliance.org
De novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A has …

Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion

USA Stalmann, F Ticconi, IAM Snoeren, R Li… - Blood …, 2022 - ashpublications.org
How genetic haploinsufficiency contributes to the clonal dominance of hematopoietic stem
cells (HSCs) in del(5q) myelodysplastic syndrome (MDS) remains unresolved. Using a …

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

F Schreibing, M Hannani, F Ticconi, E Fewings… - BioRxiv, 2021 - biorxiv.org
The current COVID-19 pandemic represents a global challenge. A better understanding of the
immune response against SARS-CoV-2 is key to unveil the differences in disease severity …

[HTML][HTML] Cyclin E1 in murine and human liver cancer: a promising target for therapeutic intervention during tumour progression

…, U Haas, D Lambertz, A Kroh, T Cramer, F Ticconi… - Cancers, 2021 - mdpi.com
Simple Summary The cell cycle regulator Cyclin E1 is a key mediator and biomarker of liver
cancer progression in mice and man independent of its canonical interacting partner Cyclin-…

Device monitoring of heart failure in cardiac resynchronization therapy device recipients: a single-center experience with a novel multivector impedance monitoring …

…, DG Della Rocca, A Politano, F Ticconi… - Journal of …, 2013 - journals.lww.com
Objectives We investigated the performance of a new intrathoracic multivector impedance
monitoring system for the prediction of heart failure events in consecutive device-implanted …

[HTML][HTML] Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile …

…, N Fischer, K Ohl, B Denecke, F Ticconi… - Arthritis Research & …, 2018 - Springer
Background The term systemic juvenile idiopathic arthritis (sJIA) describes an autoinflammatory
condition characterized by arthritis and severe systemic inflammation, which in later …