A functional immune system depends on the appropriate activation of lymphocytes following
antigen encounter. In this Review, we summarize studies that have used high-resolution …

… Weber & FD Batista, unpublished data). The contraction response results in dramatic
reorganization within the B cell membrane and formation of the mature immunological synapse (IS)…

The appropriate activation of B cells is critical for the development and operation of immune
responses and is dependent on the extensive coordination of intra- and intercellular …

Soluble antigen binds to the B-cell antigen receptor and is internalized for subsequent
processing and the presentation of antigen-derived peptides to T cells 1 . Many antigens are not …

The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …

Adaptive B cell responses are initiated by B cell receptor–antigen engagement. Despite its
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …

Initiation and affinity maturation of the humoral immune response is driven by antigen
interaction with BCR. To study how signaling and antigen presentation through BCR depend on …

B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and
are most effectively activated by membrane-bound ligands. Here, we show that in the early …

Here we describe the spatiotemporal architecture, at high molecular resolution, of receptors
and signaling molecules during the early events of mouse B cell activation. In response to …

… As we have previously shown (Batista and Neuberger, 1998), this antibody does not compete
with the binding of the MD4 BCR. As shown in Figure 3E, when MD4 B cells were settled …