Constitutive proteasomes and immunoproteasomes shape the peptide repertoire presented
by major histocompatibility complex class I (MHC-I) molecules by harboring different sets of …

Mammalian genomes encode seven catalytic proteasome subunits, namely, β1c, β2c, β5c (assembled
into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into …

Biogenesis of the 20S proteasome is tightly regulated. The N-terminal propeptides protecting
the active-site threonines are autocatalytically released only on completion of assembly. …

The heptameric proteasome activator (PA) 28αβ is known to modulate class I antigen
processing by docking onto 20S proteasome core particles (CPs). The exact stoichiometry and …

Inhibition of the 20S proteasome by bortezomib (Velcade) constitutes a successfully applied
therapy for blood cancer. However, emerging resistance restricts its medicinal use. For …

The CCAAT box is a frequent element of eukaryotic promoters, and its specific recognition
by the conserved heterotrimeric CCAAT-binding complex (CBC) constitutes a key step in …

Background The CCAAT binding complex (CBC), consisting of a heterotrimeric core structure,
is highly conserved in eukaryotes and constitutes an important general transcriptional …

Nature provides a rich source of compounds with diverse chemical structures and biological
activities, among them, sulfur‐containing metabolites from bacteria and fungi. Some of these …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2,5‐diketopiperazine
scaffold built from two amino acids and bridged by a sulfide moiety. …

Cleavage analyses of 20S proteasomes with natural or synthetic substrates allowed to infer
the substrate specificities of the active sites and paved the way for the rational design of high-…