Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …

Lung disease is a major cause of death in the United States, with current therapeutic
approaches serving only to manage symptoms. The most common chronic and life-threatening …

Mutations play a fundamental role in the development of cancer, and many create
targetable vulnerabilities. There are both public health and basic science benefits from the …

Lung cancer is one of the leading cancer malignancies, with a five-year survival rate of only
∼15%. We have developed a lentiviral-vector-mediated mouse model, which enables …

Heterochromatic repetitive satellite RNAs are extensively transcribed in a variety of human
cancers, including BRCA1 mutant breast cancer. Aberrant expression of satellite RNAs in …

X-linked Severe Combined Immunodeficiency (SCID-X1) is a genetic disease that leaves
newborns at high risk of serious infection and a predicted life span of less than 1 year in the …

Epithelial tissues such as lung and skin are exposed to the environment and therefore
particularly vulnerable to damage during injury or infection. Rapid repair is therefore essential to …

Recent advances in electron cryomicroscopy instrumentation and single particle reconstruction
have created opportunities for high-throughput and high-resolution three-dimensional (…

Small cell lung cancer (SCLC) is the most deadly subtype of lung cancer due to its dismal
prognosis. We have developed a lentiviral vector-mediated SCLC mouse model and have …

Herpes simplex virus (HSV) establishes latent infection in long‐lived neurons. During initial
infection, neurons are exposed to multiple inflammatory cytokines but the effects of immune …