Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications, which
can affect their activity, localization, and stability. The most prevalent internal modification …

RNA–protein interactions are central to cardiac function, but how activity of individual RNA-binding
protein is regulated through signaling cascades in cardiomyocytes during heart …

The mechanistic target of rapamycin (mTOR) promotes pathological remodeling in the heart
by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in …

RNA-binding proteins (RBPs) control critical aspects of cardiomyocyte function, but the
repertoire of active RBPs in cardiomyocytes during the growth response is largely unknown. We …

Pathological cardiac hypertrophy is an independent risk for heart failure (HF) and sudden
death. Deciphering signaling pathways regulating intracellular Ca 2+ homeostasis that control …

Background: Cardiac dysfunction is typically associated with altered signal transduction
pathways in cardiac myocytes, affecting both gene and protein expression. The control of the …

The mechanistic target of rapamycin (mTOR) is a key regulator of pathological remodeling
in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in …

Objective Our experiments showed that Ybx-1 is upregulated in mice two days after pressure
overload. In our study, we planned to characterize the role of Ybx-1 and identify mRNAs …

Objectives A cardiomyocyte genome-wide screen approach was used to identify mTOR-dependent
changes in gene expression at the level of mRNA translation that mediates cardiac …

Background Changes in cellular phenotype result from underlying changes in mRNA
transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated …