Tumour metastasis is a complex process involving reciprocal interplay between cancer cells
and host stroma at both primary and secondary sites, and is strongly influenced by …

To the Editor: The generation of large-scale phosphoproteomics data sets to elucidate the
phosphorylation events associated with a given phenotype or disease condition has become …

Analyzing proteins from single cells by tandem mass spectrometry (MS) has recently become
technically feasible. While such analysis has the potential to accurately quantify thousands …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC),
we generated a prognostic LSC-associated miRNA signature derived from functionally …

Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state
heterogeneity and distinct cellular signaling patterns that remain obscured with …

Large-scale single-cell analyses are of fundamental importance in order to capture
biological heterogeneity within complex cell systems, but have largely been limited to RNA-based …

Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb
signaling networks. However, global analysis of these events is currently limited. Here, we …

The basement membrane (BM) is a special type of extracellular matrix and presents the
major barrier cancer cells have to overcome multiple times to form metastases. Here we show …

Cells employ highly dynamic signaling networks to drive biological decision processes.
Perturbations to these signaling networks may attract cells to new malignant signaling and …

Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …