User profiles for Erick Strauss

Erick Strauss

Professor of Biochemistry, Stellenbosch University (South Africa)
Verified email at sun.ac.za
Cited by 2665

The biosynthesis of coenzyme A in bacteria

TP Begley, C Kinsland, E Strauss - Vitamins & Hormones, 2001 - Elsevier
Coenzyme A (I) and enzyme-bound phosphopantetheine (II) function as acyl carriers and as
carbonyl activating groups for Claisen reactions as well as for amide-, ester-, and thioester-…

Coenzyme A: to make it or uptake it?

OCM Sibon, E Strauss - Nature reviews Molecular cell biology, 2016 - nature.com
The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de
novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, …

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

…, C Spry, YM Hyun, E Strauss… - ACS medicinal …, 2013 - ACS Publications
Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin
precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has …

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

…, JY Blay, L Shintu, JC Martin, E Strauss… - Life Science …, 2018 - life-science-alliance.org
Like other tumors, aggressive soft tissue sarcomas (STS) use glycolysis rather than mitochondrial
oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor …

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

Y Ge, BG Lawhorn, M ElNaggar, E Strauss… - Journal of the …, 2002 - ACS Publications
The structural characterization of proteins expressed from the genome is a major problem in
proteomics. The solution to this problem requires the separation of the protein of interest …

[HTML][HTML] The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite

E Strauss, TP Begley - Journal of Biological Chemistry, 2002 - ASBMB
Pantothenic acid (vitamin B 5 ) is the natural precursor of coenzyme A (CoA), an essential
cofactor in all organisms. The pantothenic acid antimetaboliteN-pentylpantothenamide inhibits …

[HTML][HTML] Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

…, C Macuamule, Z Lin, KG Virga, RE Lee, E Strauss… - PloS one, 2013 - journals.plos.org
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an
extracellular supply of pantothenate (vitamin B 5 ) and is susceptible to inhibition by …

[HTML][HTML] Phosphopantothenoylcysteine synthetase from Escherichia coli: identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in …

E Strauss, C Kinsland, Y Ge, FW McLafferty… - Journal of Biological …, 2001 - ASBMB
Phosphopantothenoylcysteine synthase catalyzes the formation of (R)-4′-phospho-N-pantothenoylcysteine
from 4′-phosphopantothenate and l-cysteine: this enzyme, involved in the …

[HTML][HTML] Characterization of a new pantothenate kinase isoform from Helicobacter pylori

LA Brand, E Strauss - Journal of Biological Chemistry, 2005 - ASBMB
Pantothenate kinase (PanK) catalyzes the first step in the biosynthesis of the essential and
ubiquitous cofactor coenzyme A (CoA) in all organisms. Two well characterized isoforms of …

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

…, M de Villiers, E Strauss - Biochemical Society …, 2014 - portlandpress.com
The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl
carrier in all organisms, have long been regarded as excellent targets for the development of …