User profiles for Erick Strauss
Erick StraussProfessor of Biochemistry, Stellenbosch University (South Africa) Verified email at sun.ac.za Cited by 2665 |
The biosynthesis of coenzyme A in bacteria
TP Begley, C Kinsland, E Strauss - Vitamins & Hormones, 2001 - Elsevier
Coenzyme A (I) and enzyme-bound phosphopantetheine (II) function as acyl carriers and as
carbonyl activating groups for Claisen reactions as well as for amide-, ester-, and thioester-…
carbonyl activating groups for Claisen reactions as well as for amide-, ester-, and thioester-…
Coenzyme A: to make it or uptake it?
OCM Sibon, E Strauss - Nature reviews Molecular cell biology, 2016 - nature.com
The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de
novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, …
novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, …
Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity
Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin
precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has …
precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has …
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
Like other tumors, aggressive soft tissue sarcomas (STS) use glycolysis rather than mitochondrial
oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor …
oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor …
Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry
The structural characterization of proteins expressed from the genome is a major problem in
proteomics. The solution to this problem requires the separation of the protein of interest …
proteomics. The solution to this problem requires the separation of the protein of interest …
[HTML][HTML] The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite
E Strauss, TP Begley - Journal of Biological Chemistry, 2002 - ASBMB
Pantothenic acid (vitamin B 5 ) is the natural precursor of coenzyme A (CoA), an essential
cofactor in all organisms. The pantothenic acid antimetaboliteN-pentylpantothenamide inhibits …
cofactor in all organisms. The pantothenic acid antimetaboliteN-pentylpantothenamide inhibits …
[HTML][HTML] Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an
extracellular supply of pantothenate (vitamin B 5 ) and is susceptible to inhibition by …
extracellular supply of pantothenate (vitamin B 5 ) and is susceptible to inhibition by …
[HTML][HTML] Phosphopantothenoylcysteine synthetase from Escherichia coli: identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in …
Phosphopantothenoylcysteine synthase catalyzes the formation of (R)-4′-phospho-N-pantothenoylcysteine
from 4′-phosphopantothenate and l-cysteine: this enzyme, involved in the …
from 4′-phosphopantothenate and l-cysteine: this enzyme, involved in the …
[HTML][HTML] Characterization of a new pantothenate kinase isoform from Helicobacter pylori
LA Brand, E Strauss - Journal of Biological Chemistry, 2005 - ASBMB
Pantothenate kinase (PanK) catalyzes the first step in the biosynthesis of the essential and
ubiquitous cofactor coenzyme A (CoA) in all organisms. Two well characterized isoforms of …
ubiquitous cofactor coenzyme A (CoA) in all organisms. Two well characterized isoforms of …
Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development
…, M de Villiers, E Strauss - Biochemical Society …, 2014 - portlandpress.com
The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl
carrier in all organisms, have long been regarded as excellent targets for the development of …
carrier in all organisms, have long been regarded as excellent targets for the development of …