Bone marrow (BM) contains hematopoietic stem cells (HSCs), which differentiate into every
type of mature blood cell; endothelial cell progenitors; and marrow stromal cells, also called …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in
injured organs and have both the inflammatory features of macrophages and the tissue …

The pleiotropic growth factor TGFβ 1 promotes many of the pathogenic mechanisms observed
in lung fibrosis and airway remodeling, such as aberrant extracellular matrix deposition …

Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated
by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop …

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with
poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections…

Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over
species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic …

Fibrocytes are circulating mesenchymal progenitor cells that participate in tissue responses
to injury and invasion. Accumulating knowledge from animal models regarding the …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …