Mitofusins (Mfns) are dynamin-related GTPases that mediate mitochondrial outer-membrane
fusion, a process that is required for mitochondrial and cellular health. In Mfn1 and Mfn2 …

Mitofusins are members of the dynamin-related protein family of large GTPases that harness
the energy from nucleotide hydrolysis to remodel membranes. Mitofusins possess four …

Therapeutic antibodies are an important and rapidly growing drug modality. However, the
design and discovery of early-stage antibody therapeutics remain a time and cost-intensive …

Mitochondrial dynamics are crucial for cellular health as perturbations in these processes
which include mitochondrial fusion, division, transport and mitophagy are associated with …

Antibody therapies represent a valuable tool to reduce COVID-19 deaths and hospitalizations.
Multiple antibody candidates have been granted emergency use authorization by the …

The dataset presented here contains quantitative binding scores of scFv-format antibodies
against a SARS-CoV-2 target peptide collected via an AlphaSeq assay that can be used in …

Treating rapidly evolving pathogenic diseases such as COVID-19 requires a therapeutic
approach that accommodates the emergence of viral variants over time. Our machine learning (…

Antibody therapies represent a valuable tool to reduce COVID-19 deaths and hospitalizations.
Multiple antibody candidates have been granted emergency use authorization by the FDA …

Background Although cytokine therapies have demonstrated curative effects in some cancer
patients, clinical use remains limited due to inflammatory toxicity profiles accompanying …

Here, we demonstrate a novel approach for generating affinity detuned cytokines that can
be fused to antibodies for selective immune cell activation to improve anti-tumor responses …