Metaplastic breast carcinoma (MBC) is relatively rare but accounts for a significant proportion
of global breast cancer mortality. This group is extremely heterogeneous and by definition …

Background Metaplastic breast carcinoma encompasses a heterogeneous group of
tumours with differentiation into squamous and/or spindle, chondroid, osseous or rhabdoid …

Glandular structural features are important for the tumor pathologist in the assessment of
cancer malignancy of prostate tissue slides. The varying shapes and sizes of glands combined …

Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but
how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) …

Purpose Nuclear pleomorphic patterns are essential for Fuhrman grading of clear cell renal
cell carcinoma (ccRCC). Manual observation of renal histopathologic slides may lead to …

The disciplines of oncology and pathology are at present experiencing a wave of changes
as precision medicine becomes embedded as standard-of-care. Consequently, the need to …

Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer,
characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of …

In vitro studies have suggested proteasome inhibitors could be effective in triple-negative
breast cancer (TNBC). We found that bortezomib and carfilzomib induce proteotoxic stress and …

We aimed to identify a prostate cancer DNA hypermethylation microarray signature (denoted
as PHYMA) that differentiates prostate cancer from benign prostate hyperplasia (BPH), high …

We present an AdaBoost-based Ensemble Learning for supporting automated Gleason
grading of prostate adenocarcinoma (PRCA). The method is able to differentiate Gleason …