The operations within a living cell depend on the collective activity of networks of proteins,
sometimes termed “interactomes”. Within these networks, most proteins interact with few …

“What’s in a name? That which we call a rose By any other name would smell as sweet.”
From “Romeo and Juliet”, William Shakespeare (1594) This article opens a series of …

In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in
part through the co-transcriptional gene silencing of transposon insertions. In Drosophila …

Nuclear pore complexes (NPCs) are huge assemblies formed from ∼30 different nucleoporins,
typically organized in subcomplexes. One module, the conserved Nup82 complex at the …

10.7554/eLife.36258.001 The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually
high number of recognition motifs for the product of its main target gene, the hub protein …

The dynein light chain LC8 is an integral subunit of the cytoplasmic dynein motor complex
that binds directly to and promotes assembly of the dynein intermediate chain (IC). LC8 …

Hydroxyproline (Hyp) O-glycosylation characterizes the hydroxyproline-rich glycoprotein (HRGP)
superfamily of the plant extracellular matrix. Hyp glycosylation occurs in two modes: …

The interactions of three subunits of cytoplasmic dynein from Drosophila melanogaster, LC8,
Tctex-1, and the N-terminal domain of IC74 (N-IC74, residues 1−289), were characterized …

Dynein light chains are thought to increase binding efficiency of dynein intermediate chain
to both dynein heavy chain and dynactin, but their exact role is not clear. Isothermal titration …

The nucleocapsid phosphoprotein N plays critical roles in multiple processes of the severe
acute respiratory syndrome coronavirus 2 infection cycle: it protects and packages viral RNA …