Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

…, A Adamopoulos, T Kuijt, M Ubbink, E Von Castelmur… - Science, 2015 - science.org
Cell division progresses to anaphase only after all chromosomes are connected to spindle
microtubules through kinetochores and the spindle assembly checkpoint (SAC) is satisfied. …

PLA2G16 represents a switch between entry and clearance of Picornaviridae

J Staring, E von Castelmur, VA Blomen… - Nature, 2017 - nature.com
Picornaviruses are a leading cause of human and veterinary infections that result in various
diseases, including polio and the common cold. As archetypical non-enveloped viruses, …

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

W Nijenhuis, E Von Castelmur, D Littler… - Journal of Cell …, 2013 - rupress.org
The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle
progression until all kinetochores have attached to the mitotic spindle. In this paper, we show that …

[PDF][PDF] The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase

…, TJP van Dam, GE Karagöz, E von Castelmur… - Developmental cell, 2012 - cell.com
Chromosomal stability is safeguarded by a mitotic checkpoint, of which BUB1 and Mad3/BUBR1
are core components. These paralogs have similar, but not identical, domain …

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

E Von Castelmur, M Marino… - Proceedings of the …, 2008 - National Acad Sciences
Myofibril elasticity, critical to muscle function, is dictated by the intrasarcomeric filament titin,
which acts as a molecular spring. To date, the molecular events underlying the mechanics of …

Molecular determinants for the recruitment of the ubiquitin‐ligase MuRF‐1 onto M‐line titin

…, S Witt, H Heerklotz, E von Castelmur… - The FASEB …, 2007 - Wiley Online Library
Titin forms an intrasarcomeric filament system in vertebrate striated muscle, which has
elastic and signaling properties and is thereby central to mechanotransduction. Near its C‐…

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

…, S Meier, Z Ucurum-Fotiadis, E von Castelmur… - Biochemistry, 2008 - ACS Publications
The B-box motif is the defining feature of the TRIM family of proteins, characterized by a RING
finger−B-box−coiled coil tripartite fold. We have elucidated the crystal structure of B-box 2 (…

Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity

…, A Norberg, Y Zhang, E Von Castelmur… - Human Molecular …, 2023 - academic.oup.com
Telomere biology disorders (TBDs) are characterized by short telomeres, premature aging,
bone marrow failure and cancer predisposition. Germline mutations in NHP2, encoding for …

Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study

…, D Derbyshire, E von Castelmur… - The Journal of …, 2023 - ACS Publications
Misfolding and aggregation of transthyretin (TTR) cause several amyloid diseases. Besides
being an amyloidogenic protein, TTR has an affinity for bicyclic small-molecule ligands in its …

Transthyretin Binding Mode Dichotomy of Fluorescent trans-Stilbene Ligands

…, P Hammarström, E von Castelmur - ACS chemical …, 2023 - ACS Publications
The orientations of ligands bound to the transthyretin (TTR) thyroxine (T4) binding site are
difficult to predict. Conflicting binding modes of resveratrol have been reported. We previously …