Safety and effectiveness of up to 3 years' bulevirtide monotherapy in patients with HDV-related cirrhosis
…, R Perbellini, A Rimondi, E Farina, E Trombetta… - Journal of …, 2022 - Elsevier
The entry inhibitor bulevirtide (BLV) received conditional approval from the EMA in July 2020
for the treatment of adult patients with compensated chronic hepatitis delta. However, the …
for the treatment of adult patients with compensated chronic hepatitis delta. However, the …
Integrative analysis reveals a molecular stratification of systemic autoimmune diseases
…, A Tavares, C Vasconcelos, E Trombetta… - Arthritis & …, 2021 - Wiley Online Library
Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes
early diagnosis and effective treatment, issues that may be addressed if patients could be …
early diagnosis and effective treatment, issues that may be addressed if patients could be …
[HTML][HTML] Early phases of COVID-19 are characterized by a reduction in lymphocyte populations and the presence of atypical monocytes
A Lombardi, E Trombetta, A Cattaneo… - Frontiers in …, 2020 - frontiersin.org
Background Severe acute respiratory syndrome coronavirus 2 is a recently discovered
pathogen responsible of coronavirus disease 2019 (COVID-19). The immunological changes …
pathogen responsible of coronavirus disease 2019 (COVID-19). The immunological changes …
Excellent safety and effectiveness of high-dose myrcludex-B monotherapy administered for 48 weeks in HDV-related compensated cirrhosis: A case report of 3 …
…, M Borghi, H Holzmann, R Perbellini, E Trombetta… - Journal of …, 2019 - Elsevier
Short-term administration of the entry inhibitor myrcludex-B (MyrB) has been shown to be
safe and effective in phase II studies in patients coinfected with hepatitis B virus (HBV) and …
safe and effective in phase II studies in patients coinfected with hepatitis B virus (HBV) and …
[HTML][HTML] The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma
…, C Patrizi, S Marinelli, C Giovannini, E Trombetta… - Cell death & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality
worldwide and is associated with poor prognosis, especially in patients not amenable for …
worldwide and is associated with poor prognosis, especially in patients not amenable for …
[HTML][HTML] iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis
iNKT cells account for a relevant fraction of effector T-cells in the intestine and are considered
an attractive platform for cancer immunotherapy. Although iNKT cells are cytotoxic …
an attractive platform for cancer immunotherapy. Although iNKT cells are cytotoxic …
[HTML][HTML] CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis
…, L Beretta, N Vazirpanah, E Trombetta… - Journal of …, 2020 - Elsevier
Objective To analyze how monocyte and macrophage exposure to CXCL4 induces inflammatory
and fibrotic processes observed in Systemic sclerosis (SSc) patients. Methods In six …
and fibrotic processes observed in Systemic sclerosis (SSc) patients. Methods In six …
[HTML][HTML] Tumor-educated platelets and angiogenesis in glioblastoma: another brick in the wall for novel prognostic and targetable biomarkers, changing the vision …
…, L Guarnaccia, C Cordiglieri, E Trombetta… - Cells, 2020 - mdpi.com
Circulating platelets (PLTs) are able to affect glioblastoma (GBM) microenvironment by
supplying oncopromoter and pro-angiogenic factors. Among these mediators, sphingosine-1-…
supplying oncopromoter and pro-angiogenic factors. Among these mediators, sphingosine-1-…
[HTML][HTML] Angiogenesis in human brain tumors: Screening of drug response through a patient-specific cell platform for personalized therapy
L Guarnaccia, SE Navone, E Trombetta, C Cordiglieri… - Scientific reports, 2018 - nature.com
Gliomas are the most common brain tumors, with diverse biological behaviour. Glioblastoma
(GBM), the most aggressive and with the worst prognosis, is characterized by an intense …
(GBM), the most aggressive and with the worst prognosis, is characterized by an intense …
Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting
…, CGK Wichers, L Beretta, E Trombetta… - Annals of the …, 2019 - ard.bmj.com
Background and objective Systemic sclerosis (SSc) is a severe autoimmune disease, in
which the pathogenesis is dependent on both genetic and epigenetic factors. Altered gene …
which the pathogenesis is dependent on both genetic and epigenetic factors. Altered gene …