User profiles for Ekaterina Nevedomskaya
Ekaterina NevedomskayaScientist, Bayer AG Verified email at bayer.com Cited by 2777 |
[HTML][HTML] Recent advances in prostate cancer treatment and drug discovery
E Nevedomskaya, SJ Baumgart… - International journal of …, 2018 - mdpi.com
Novel drugs, drug sequences and combinations have improved the outcome of prostate
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
…, R Lopes, AP Ugalde, E Nevedomskaya… - Nature …, 2016 - nature.com
Systematic identification of noncoding regulatory elements has, to date, mainly relied on
large-scale reporter assays that do not reproduce endogenous conditions. We present two …
large-scale reporter assays that do not reproduce endogenous conditions. We present two …
[HTML][HTML] From omics to multi-omics approaches for in-depth analysis of the molecular mechanisms of prostate cancer
E Nevedomskaya, B Haendler - International Journal of Molecular …, 2022 - mdpi.com
Cancer arises following alterations at different cellular levels, including genetic and epigenetic
modifications, transcription and translation dysregulation, as well as metabolic variations. …
modifications, transcription and translation dysregulation, as well as metabolic variations. …
[HTML][HTML] CopywriteR: DNA copy number detection from off-target sequence data
…, L Bombardelli, M Hoogstraat, E Nevedomskaya… - Genome biology, 2015 - Springer
Current methods for detection of copy number variants (CNV) and aberrations (CNA) from
targeted sequencing data are based on the depth of coverage of captured exons. Accurate …
targeted sequencing data are based on the depth of coverage of captured exons. Accurate …
[PDF][PDF] APOBEC3B-mediated cytidine deamination is required for estrogen receptor action in breast cancer
…, H Patel, CF Lai, VTM Nguyen, E Nevedomskaya… - Cell reports, 2015 - cell.com
Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast
cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER …
cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER …
[HTML][HTML] Integrative epigenetic taxonomy of primary prostate cancer
The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly
controlled by epigenetic regulation. To date, most epigenetic profiling has been performed …
controlled by epigenetic regulation. To date, most epigenetic profiling has been performed …
[HTML][HTML] Preclinical Anticipation of On-and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review
PJ Dziubańska-Kusibab, E Nevedomskaya… - International Journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
Exploratory analysis of human urine by LC–ESI-TOF MS after high intake of olive oil: Understanding the metabolism of polyphenols
…, A Carrasco-Pancorbo, E Nevedomskaya… - Analytical and …, 2010 - Springer
Olive oil polyphenols have important biological properties which closely depend on their
bioavailability; it is, therefore, essential to understand how polyphenols are absorbed, …
bioavailability; it is, therefore, essential to understand how polyphenols are absorbed, …
Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
Androgen receptor (AR) is a key player in prostate cancer development and progression. Here
we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to …
we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to …
Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐and CXCL8‐mediated cancer cell migration
B Cioni, E Nevedomskaya, MHM Melis… - Molecular …, 2018 - Wiley Online Library
Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including
cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. …
cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. …