Control measures have significantly reduced malaria morbidity and mortality in the last two
decades; however, the downward trends have stalled and have become complicated by the …

Malaria is among the most serious infectious diseases affecting humans, accounting for
approximately half a million deaths each year 1 . Plasmodium falciparum causes most life-…

Malaria causes about 216 million clinical cases and 0.7 million deaths annually. One
promising route to address malaria is vaccination. However, so far, not even a single licensed …

Recently, there has been a renewed interest in the development of transmission-blocking
vaccines (TBV) against Plasmodium falciparum malaria. While several candidate TBVs have …

Existing control measures have significantly reduced malaria morbidity and mortality in the
last two decades, although these reductions are now stalling. Significant efforts have been …

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals
carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study …

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the
presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally …

10.7554/eLife.28673.001 The study of antigenic targets of naturally-acquired immunity is
essential to identify and prioritize antigens for further functional characterization. We measured …

An insertional mutation in hsa, the gene encoding the sialic acid-binding adhesin of
Streptococcus gordonii DL1, resulted in a significant reduction of the infection rate of the organism …