Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT),
there has been a rapid proliferation in the description of new non-histone targets of HATs. Of …

Transcriptional repression by nuclear receptors has been correlated to binding of the
putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad …

Transcriptional repression by Mad–Max heterodimers requires interaction of Mad with the
corepressors mSin3A/B. Sin3p, the S. cerevisiae homolog of mSin3, functions in the same …

Lysine acetylation has emerged as a major posttranslational modification for histones.
Crossregulation between this and other modifications is crucial in modulating chromatin-based …

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there are …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

A sequence within the transcription control region of the adeno-associated virus P5 promoter
has been shown to mediate transcriptional activation by the adenovirus EIA protein. We …

Over the last several decades, it has become clear that epigenetic abnormalities may be
one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may …

The hydroxamic acid (HAA) analogue pan-histone deacetylase (HDAC) inhibitors (HDIs)
LAQ824 and LBH589 have been shown to induce acetylation and inhibit the ATP binding and …

A key event in the regulation of eukaryotic gene expression is the posttranslational modification
of nucleosomal histones, which converts regions of chromosomes into transcriptionally …