The “integrin” terminology was applied in a 1987 review article (1) to describe a family of
structurally, immunochemically, and functionally related cell-surface heterodimeric receptors, …

Platelets have a key role in atherosclerosis, thrombosis, and acute coronary syndromes.
Therapeutic manipulation of platelet function has focused principally on the use of aspirin, …

The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within fibronectin
that mediates cell attachment. The RGD motif has now been found in numerous other …

Adhesive interactions of the platelet surface with plasma proteins such as fibrinogen and
fibronectin play an important role in thrombosis and hemostasis. The binding of both of these …

Revised Manuscript Received October 31, 1990 abstract: Plasminogen binding to cell
surfaces results in enhanced plasminogen activation, localization of the proteolyticactivity of …

The Arg-Gly-Asp sequence resides in the cell attachment region of fibronectin. Arg-Gly-Asp-containing
peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, …

Regardless of the event that stimulates the aggregation of platelets, the receptor α llb β 3 -one
of a family of adhesion receptors known as integrins–has a key role in the process. The …

Activation of the ligand binding function of integrin heterodimers requires transmission of an
"inside-out" signal from their small intracellular segments to their large extracellular domains…

Many similarities exist in the cellular responses elicited by VEGF and governed by integrins.
Here, we identify a basis for these interrelationships: VEGF activates integrins. VEGF …

LIPOPROTEIN(a) (Lp(a)) has been strongly linked with atherosclerosis and is an
independent risk factor for myocardial infarction 1–6 . Distinguishing Lp(a) from other low-density …