User profiles for Edward C Holmes

Edward C Holmes

University of Sydney
Verified email at sydney.edu.au
Cited by 143266

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

…, Z Xie, J Ma, WJ Liu, D Wang, W Xu, EC Holmes… - The lancet, 2020 - thelancet.com
Background In late December, 2019, patients presenting with viral pneumonia due to an
unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was …

[HTML][HTML] A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

A Rambaut, EC Holmes, Á O'Toole, V Hill… - Nature …, 2020 - nature.com
The ongoing pandemic spread of a new human coronavirus, SARS-CoV-2, which is associated
with severe pneumonia/disease (COVID-19), has resulted in the generation of tens of …

[PDF][PDF] A genomic perspective on the origin and emergence of SARS-CoV-2

YZ Zhang, EC Holmes - Cell, 2020 - cell.com
The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous
global concern. We and others in China were involved in the initial genome sequencing of …

Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool

…, SW Attwood, DM Aanensen, EC Holmes… - Virus …, 2021 - academic.oup.com
The response of the global virus genomics community to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic has been unprecedented, with significant …

Cross-species virus transmission and the emergence of new epidemic diseases

CR Parrish, EC Holmes, DM Morens… - Microbiology and …, 2008 - Am Soc Microbiol
Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts. …

Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses

…, XD Lin, YJ Kang, LJ Chen, XC Qin, J Xu, EC Holmes… - elife, 2015 - elifesciences.org
10.7554/eLife.05378.001 Although arthropods are important viral vectors, the biodiversity of
arthropod viruses, as well as the role that arthropods have played in viral origins and …

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis

…, A Rambaut, OG Pybus, EC Holmes - Journal of molecular …, 2002 - Springer
The study of rates of nucleotide substitution in RNA viruses is central to our understanding of
their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA …

Evolutionary aspects of recombination in RNA viruses

M Worobey, EC Holmes - Journal of General Virology, 1999 - microbiologyresearch.org
RNA viruses deserve their reputation as Nature’s swiftest evolvers. Their high rates of mutation
and replication (Holland et al., 1982) allow them to move through sequence space at a …

[PDF][PDF] A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein

…, H Song, Y Liu, P Wang, D Liu, J Yang, EC Holmes… - Current biology, 2020 - cell.com
The unprecedented pandemic of pneumonia caused by a novel coronavirus, SARS-CoV-2,
in China and beyond has had major public health impacts on a global scale [1, 2]. Although …

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27–restricted cytotoxic T lymphocyte responses

AD Kelleher, C Long, EC Holmes, RL Allen… - The Journal of …, 2001 - rupress.org
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte
antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (…