User profiles for Edward C Holmes
Edward C HolmesUniversity of Sydney Verified email at sydney.edu.au Cited by 143266 |
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Background In late December, 2019, patients presenting with viral pneumonia due to an
unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was …
unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was …
[HTML][HTML] A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology
The ongoing pandemic spread of a new human coronavirus, SARS-CoV-2, which is associated
with severe pneumonia/disease (COVID-19), has resulted in the generation of tens of …
with severe pneumonia/disease (COVID-19), has resulted in the generation of tens of …
[PDF][PDF] A genomic perspective on the origin and emergence of SARS-CoV-2
YZ Zhang, EC Holmes - Cell, 2020 - cell.com
The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous
global concern. We and others in China were involved in the initial genome sequencing of …
global concern. We and others in China were involved in the initial genome sequencing of …
Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool
The response of the global virus genomics community to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic has been unprecedented, with significant …
syndrome coronavirus 2 (SARS-CoV-2) pandemic has been unprecedented, with significant …
Cross-species virus transmission and the emergence of new epidemic diseases
CR Parrish, EC Holmes, DM Morens… - Microbiology and …, 2008 - Am Soc Microbiol
Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts. …
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts. …
Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses
…, XD Lin, YJ Kang, LJ Chen, XC Qin, J Xu, EC Holmes… - elife, 2015 - elifesciences.org
10.7554/eLife.05378.001 Although arthropods are important viral vectors, the biodiversity of
arthropod viruses, as well as the role that arthropods have played in viral origins and …
arthropod viruses, as well as the role that arthropods have played in viral origins and …
Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis
The study of rates of nucleotide substitution in RNA viruses is central to our understanding of
their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA …
their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA …
Evolutionary aspects of recombination in RNA viruses
RNA viruses deserve their reputation as Nature’s swiftest evolvers. Their high rates of mutation
and replication (Holland et al., 1982) allow them to move through sequence space at a …
and replication (Holland et al., 1982) allow them to move through sequence space at a …
[PDF][PDF] A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein
…, H Song, Y Liu, P Wang, D Liu, J Yang, EC Holmes… - Current biology, 2020 - cell.com
The unprecedented pandemic of pneumonia caused by a novel coronavirus, SARS-CoV-2,
in China and beyond has had major public health impacts on a global scale [1, 2]. Although …
in China and beyond has had major public health impacts on a global scale [1, 2]. Although …
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27–restricted cytotoxic T lymphocyte responses
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte
antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (…
antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (…