[PDF][PDF] RAS proteins and their regulators in human disease

DK Simanshu, DV Nissley, F McCormick - Cell, 2017 - cell.com
RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as …

[HTML][HTML] KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

…, T Taylor, JP Denson, D Esposito, DV Nissley… - Nature …, 2021 - nature.com
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, …

[HTML][HTML] ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical …

M Yi, DV Nissley, F McCormick, RM Stephens - Scientific reports, 2020 - nature.com
For nearly a decade, the difficulties associated with both the determination and reproducibility
of Ras-dependency indexes (RDIs) have limited their application and further delineation of …

Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers

…, W Burgan, M Yi, TM Guerin, SV Kozlov, DV Nissley… - Cancer research, 2020 - AACR
These findings illuminate the mechanistic features of KRAS-mediated chemoresistance and
provide a rationale for exploiting metabolic reprogramming in pancreatic cancer cells to …

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

…, PH Frank, R Ghirlando, DV Nissley… - Proceedings of the …, 2016 - National Acad Sciences
Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling events …

Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants …

T Flys, DV Nissley, CW Claasen, D Jones… - The Journal of …, 2005 - academic.oup.com
BackgroundThe HIV Network for Prevention Trials (HIVNET) 012 trial showed that NVP
resistance (NVPR) emerged in some women and children after the administration of single-dose …

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast

AJ Schumacher, DV Nissley… - Proceedings of the …, 2005 - National Acad Sciences
Human cells harbor a variety of factors that function to block the proliferation of foreign
nucleic acid. The APOBEC3G enzyme inhibits the replication of retroviruses by deaminating …

Machine learning-driven multiscale modeling: bridging the scales with a next-generation simulation infrastructure

…, JN Glosli, FC Lightstone, DV Nissley… - Journal of Chemical …, 2023 - ACS Publications
Interdependence across time and length scales is common in biology, where atomic interactions
can impact larger-scale phenomenon. Such dependence is especially true for a well-…

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

…, F McCormick, DV Nissley… - Proceedings of the …, 2022 - National Acad Sciences
RAS is a signaling protein associated with the cell membrane that is mutated in up to 30%
of human cancers. RAS signaling has been proposed to be regulated by dynamic …

Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency

…, DR Kuritzkes, KJ Metzner, DV Nissley… - Journal of clinical …, 2006 - Am Soc Microbiol
We determined the abilities of 10 technologies to detect and quantify a common drug-resistant
mutant of human immunodeficiency virus type 1 (lysine to asparagine at codon 103 of the …