[HTML][HTML] A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing

Y Chen, A Boland, D Kuzuoğlu-Öztürk, P Bawankar… - Molecular cell, 2014 - cell.com
CCR4-NOT is a major effector complex in miRNA-mediated gene silencing. It is recruited to
miRNA targets through interactions with tryptophan (W)-containing motifs in TNRC6/GW182 …

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

L Zekri, D KuzuoğluÖztürk, E Izaurralde - The EMBO journal, 2013 - embopress.org
GW182 family proteins interact with Argonaute proteins and are required for the translational
repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 …

Structure and assembly of the NOT module of the human CCR4–NOT complex

…, T Raisch, S Jonas, D Kuzuoğlu-Öztürk… - Nature structural & …, 2013 - nature.com
The CCR4–NOT deadenylase complex is a master regulator of translation and mRNA stability.
Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We …

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

E Huntzinger, D Kuzuoğlu-Öztürk, JE Braun… - Nucleic acids …, 2013 - academic.oup.com
Animal miRNAs silence the expression of mRNA targets through translational repression,
deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs …

mi RISC and the CCR 4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

D KuzuoğluÖztürk, D Bhandari, E Huntzinger… - The EMBO …, 2016 - embopress.org
mi RNA s associate with Argonaute ( AGO ) proteins to silence the expression of mRNA
targets by inhibiting translation and promoting deadenylation, decapping, and mRNA …

[HTML][HTML] A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

…, D Bhandari, Y Chen, D Kuzuoğlu-Öztürk… - Nature …, 2017 - nature.com
Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target
degradation through the recruitment of the CCR4-NOT deadenylase complex and are …

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

D Kuzuoğlu-Öztürk, E Huntzinger… - Nucleic acids …, 2012 - academic.oup.com
GW182 family proteins are essential for miRNA-mediated gene silencing in animal cells. They
are recruited to miRNA targets via interactions with Argonaute proteins and then promote …

[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

…, PP Sharp, NA Wenzell, D Kuzuoglu-Ozturk… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

[PDF][PDF] Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

…, JC Crawford, DA Rodriguez, D Kuzuoğlu-Öztürk… - Molecular cell, 2022 - cell.com
Activated CD8 + T lymphocytes differentiate into heterogeneous subsets. Using super-resolution
imaging, we found that prior to the first division, dynein-dependent vesicular transport …

Evolutionarily divergent mTOR remodels translatome for tissue regeneration

…, HD Rosenblatt, L Shokat, S Dai, D Kuzuoglu-Öztürk… - Nature, 2023 - nature.com
An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot 1 . Here, we demonstrate that rapid activation of protein …