User profiles for Duygu Kuzuoğlu-Öztürk
Duygu Kuzuoğlu-ÖztürkUCSF Verified email at ucsf.edu Cited by 5596 |
[HTML][HTML] A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing
CCR4-NOT is a major effector complex in miRNA-mediated gene silencing. It is recruited to
miRNA targets through interactions with tryptophan (W)-containing motifs in TNRC6/GW182 …
miRNA targets through interactions with tryptophan (W)-containing motifs in TNRC6/GW182 …
GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation
L Zekri, D Kuzuoğlu‐Öztürk, E Izaurralde - The EMBO journal, 2013 - embopress.org
GW182 family proteins interact with Argonaute proteins and are required for the translational
repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 …
repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 …
Structure and assembly of the NOT module of the human CCR4–NOT complex
The CCR4–NOT deadenylase complex is a master regulator of translation and mRNA stability.
Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We …
Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We …
The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets
Animal miRNAs silence the expression of mRNA targets through translational repression,
deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs …
deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs …
mi RISC and the CCR 4–NOT complex silence mRNA targets independently of 43S ribosomal scanning
mi RNA s associate with Argonaute ( AGO ) proteins to silence the expression of mRNA
targets by inhibiting translation and promoting deadenylation, decapping, and mRNA …
targets by inhibiting translation and promoting deadenylation, decapping, and mRNA …
[HTML][HTML] A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target
degradation through the recruitment of the CCR4-NOT deadenylase complex and are …
degradation through the recruitment of the CCR4-NOT deadenylase complex and are …
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes
D Kuzuoğlu-Öztürk, E Huntzinger… - Nucleic acids …, 2012 - academic.oup.com
GW182 family proteins are essential for miRNA-mediated gene silencing in animal cells. They
are recruited to miRNA targets via interactions with Argonaute proteins and then promote …
are recruited to miRNA targets via interactions with Argonaute proteins and then promote …
[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
…, PP Sharp, NA Wenzell, D Kuzuoglu-Ozturk… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …
which is the causative agent of coronavirus disease 2019 (COVID-19), has …
[PDF][PDF] Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
Activated CD8 + T lymphocytes differentiate into heterogeneous subsets. Using super-resolution
imaging, we found that prior to the first division, dynein-dependent vesicular transport …
imaging, we found that prior to the first division, dynein-dependent vesicular transport …
Evolutionarily divergent mTOR remodels translatome for tissue regeneration
…, HD Rosenblatt, L Shokat, S Dai, D Kuzuoglu-Öztürk… - Nature, 2023 - nature.com
An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot 1 . Here, we demonstrate that rapid activation of protein …
tissues whereas mammals cannot 1 . Here, we demonstrate that rapid activation of protein …