User profiles for Dimitris Thanos
Dimitris ThanosChairman of the Scientific Board, Biomedical Research Foundation Academy of Athens Verified email at bioacademy.gr Cited by 20841 |
Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers
Transcription of endothelial‐leukocyte adhesion molecule‐1 (E‐selectin or ELAM‐1), vascular
cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule‐l (ICAM‐1) is …
cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule‐l (ICAM‐1) is …
[PDF][PDF] NF-κB: a lesson in family values
D Thanos, T Maniatis - Cell, 1995 - core.ac.uk
NF-KB and the other members of the Rel family of transcriptional activator proteins have been
a focal point for understanding how extracellular signals induce the expression of specific …
a focal point for understanding how extracellular signals induce the expression of specific …
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
D Thanos, T Maniatis - Cell, 1995 - cell.com
We present evidence that transcriptional activation of the human interferon-p (IFNP) gene
requires the assembly of a higher order transcription enhancer complex (enhanceosome). This …
requires the assembly of a higher order transcription enhancer complex (enhanceosome). This …
[HTML][HTML] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter
Here, we show that the IFN-β enhanceosome activates transcription by directing the ordered
recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. …
recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. …
[HTML][HTML] Deciphering the transcriptional histone acetylation code for a human gene
T Agalioti, G Chen, D Thanos - Cell, 2002 - cell.com
We report the results of experiments designed to test the histone code hypothesis. We found
that only a small subset of lysines in histones H4 and H3 are acetylated in vivo by the GCN5 …
that only a small subset of lysines in histones H4 and H3 are acetylated in vivo by the GCN5 …
The high mobility group protein HMG I (Y) is required for NF-κB-dependent virus induction of the human IFN-β gene
D Thanos, T Maniatis - Cell, 1992 - cell.com
In this paper, we show that both NF-KB and the high mobility group protein l (Y)(HMG l (Y))
are required for virus induction of the human interferon-p (IFN-fl) gene. NF-KB binds to the …
are required for virus induction of the human interferon-p (IFN-fl) gene. NF-KB binds to the …
[PDF][PDF] Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription
M Merika, AJ Williams, G Chen, T Collins, D Thanos - Molecular cell, 1998 - cell.com
Transcriptional activation of the IFNβ gene in response to virus infection requires the assembly
of an enhanceosome, consisting of the transcriptional activators NF-κB, IRF1, ATF2/c-Jun, …
of an enhanceosome, consisting of the transcriptional activators NF-κB, IRF1, ATF2/c-Jun, …
[HTML][HTML] Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure
Excitatory and inhibitory inputs converge on single neurons and are integrated into a coherent
output. Although much is known about short-term integration, little is known about how …
output. Although much is known about short-term integration, little is known about how …
Enhanceosomes
M Merika, D Thanos - Current opinion in genetics & development, 2001 - Elsevier
Gene-specific transcriptional regulation in higher eukaryotes is mediated by complex cis-acting
control elements that specify the location, timing and magnitude of the response. During …
control elements that specify the location, timing and magnitude of the response. During …
Transcriptional activation by NF-κB requires multiple coactivators
…, E McInerney, S Westin, D Thanos… - … and cellular biology, 1999 - Am Soc Microbiol
Nuclear factor-κB (NF-κB) plays a role in the transcriptional regulation of genes involved in
inflammation and cell survival. In this report we demonstrate that NF-κB recruits a coactivator …
inflammation and cell survival. In this report we demonstrate that NF-κB recruits a coactivator …