User profiles for Dimitris Thanos

Dimitris Thanos

Chairman of the Scientific Board, Biomedical Research Foundation Academy of Athens
Verified email at bioacademy.gr
Cited by 20841

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

…, MA Read, AS Neish, MZ Whitley, D Thanos… - The FASEB …, 1995 - Wiley Online Library
Transcription of endothelial‐leukocyte adhesion molecule‐1 (E‐selectin or ELAM‐1), vascular
cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule‐l (ICAM‐1) is …

[PDF][PDF] NF-κB: a lesson in family values

D Thanos, T Maniatis - Cell, 1995 - core.ac.uk
NF-KB and the other members of the Rel family of transcriptional activator proteins have been
a focal point for understanding how extracellular signals induce the expression of specific …

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

D Thanos, T Maniatis - Cell, 1995 - cell.com
We present evidence that transcriptional activation of the human interferon-p (IFNP) gene
requires the assembly of a higher order transcription enhancer complex (enhanceosome). This …

[HTML][HTML] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter

…, S Lomvardas, B Parekh, J Yie, T Maniatis, D Thanos - Cell, 2000 - cell.com
Here, we show that the IFN-β enhanceosome activates transcription by directing the ordered
recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. …

[HTML][HTML] Deciphering the transcriptional histone acetylation code for a human gene

T Agalioti, G Chen, D Thanos - Cell, 2002 - cell.com
We report the results of experiments designed to test the histone code hypothesis. We found
that only a small subset of lysines in histones H4 and H3 are acetylated in vivo by the GCN5 …

The high mobility group protein HMG I (Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

D Thanos, T Maniatis - Cell, 1992 - cell.com
In this paper, we show that both NF-KB and the high mobility group protein l (Y)(HMG l (Y))
are required for virus induction of the human interferon-p (IFN-fl) gene. NF-KB binds to the …

[PDF][PDF] Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription

M Merika, AJ Williams, G Chen, T Collins, D Thanos - Molecular cell, 1998 - cell.com
Transcriptional activation of the IFNβ gene in response to virus infection requires the assembly
of an enhanceosome, consisting of the transcriptional activators NF-κB, IRF1, ATF2/c-Jun, …

[HTML][HTML] Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure

…, JH Kim, MC Miniaci, JH Schwartz, D Thanos… - Cell, 2002 - cell.com
Excitatory and inhibitory inputs converge on single neurons and are integrated into a coherent
output. Although much is known about short-term integration, little is known about how …

Enhanceosomes

M Merika, D Thanos - Current opinion in genetics & development, 2001 - Elsevier
Gene-specific transcriptional regulation in higher eukaryotes is mediated by complex cis-acting
control elements that specify the location, timing and magnitude of the response. During …

Transcriptional activation by NF-κB requires multiple coactivators

…, E McInerney, S Westin, D Thanos… - … and cellular biology, 1999 - Am Soc Microbiol
Nuclear factor-κB (NF-κB) plays a role in the transcriptional regulation of genes involved in
inflammation and cell survival. In this report we demonstrate that NF-κB recruits a coactivator …