TRIM E3 ubiquitin ligases regulate a wide variety of cellular processes and are particularly
important during innate immune signalling events. They are characterized by a conserved …

Temperature is a primary environmental stress to which micro-organisms must be able to
adapt and respond rapidly. Whereas some bacteria are restricted to specific niches and have …

Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …

Ras proteins signal to a number of distinct pathways by interacting with diverse effectors.
Studies of ras/effector interactions have focused on three classes, Raf kinases, ral …

Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-A 165 (VEGF-A 165
) in endothelial cells. To define the role of NP-1 in the biological functions of VEGF, we …

H-NS plays a role in condensing DNA in the bacterial nucleoid. This 136 amino acid protein
comprises two functional domains separated by a flexible linker. High order structures …

Multidomain proteins incorporating interaction domains are central to regulation of cellular
processes. The elucidation of structural organization and mechanistic insights into many of …

TRIM proteins form a protein family that is characterized by a conserved tripartite motif domain
comprising a RING domain, one or two B-box domains and a coiled-coil region. Members …

Background Following the amputation of a limb, newts and salamanders have the capability
to regenerate the lost tissues via a complex process that takes place at the site of injury. …

Several isoforms of phospholipase C (PLC) are regulated through interactions with Ras
superfamily GTPases, including Rac proteins. Interestingly, of two closely related PLCγ isoforms, …