User profiles for Derek Van Booven
 | Derek Van BoovenDirector Research Data, John P Hussman Insitute for Human Genomics, University of Miami Verified email at med.miami.edu Cited by 2955 |
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
Background— Much has been learned about transcriptional control of cardiac gene
expression in clinical and experimental congestive heart failure (CHF), but less is known about …
expression in clinical and experimental congestive heart failure (CHF), but less is known about …
Cytochrome P450 2C9-CYP2C9
D Van Booven, S Marsh, H McLeod… - Pharmacogenetics …, 2010 - journals.lww.com
CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et al.[…
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et al.[…
[HTML][HTML] Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders
…, I Konidari, RC Gentry, WF Hulme, DV Booven… - Molecular autism, 2014 - Springer
Background Autism spectrum disorders (ASDs) comprise a range of neurodevelopmental
conditions of varying severity, characterized by marked qualitative difficulties in social …
conditions of varying severity, characterized by marked qualitative difficulties in social …
[HTML][HTML] Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
…, JP Gue, J Cabezas, JJ Lozano, D Van Booven… - Nature …, 2019 - nature.com
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular
dysfunction for which targeted treatments are urgently needed. Identification of molecular …
dysfunction for which targeted treatments are urgently needed. Identification of molecular …
[HTML][HTML] Convergent pathways in idiopathic autism revealed by time course transcriptomic analysis of patient-derived neurons
…, C Garcia-Serje, AW Phillips, D Van Booven… - Scientific reports, 2018 - nature.com
Potentially pathogenic alterations have been identified in individuals with autism spectrum
disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a …
disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a …
ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
…, PL Whitehead, BA Dombroski, D Van Booven… - Neurology …, 2016 - AAN Enterprises
Objective: To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in
African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7…
African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7…
RISC RNA sequencing for context-specific identification of in vivo microRNA targets
SJ Matkovich, DJ Van Booven… - Circulation …, 2011 - Am Heart Assoc
Rationale: MicroRNAs (miRs) are expanding our understanding of cardiac disease and
have the potential to transform cardiovascular therapeutics. One miR can target hundreds of …
have the potential to transform cardiovascular therapeutics. One miR can target hundreds of …
A systematic review of artificial intelligence in prostate cancer
The diagnosis and management of prostate cancer involves the interpretation of data from
multiple modalities to aid in decision making. Tools like PSA levels, MRI guided biopsies, …
multiple modalities to aid in decision making. Tools like PSA levels, MRI guided biopsies, …
[HTML][HTML] Epigenetic reprogramming of melanoma cells by vitamin C treatment
…, C Yang, KM Dickson, H Shao, D Van Booven… - Clinical …, 2015 - Springer
Background The loss of 5-hydroxymethylcytosine (5hmC) has been identified as a novel
epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC …
epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC …
Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation
…, W Wang, D Van Booven… - Proceedings of the …, 2011 - National Acad Sciences
Common heart failure has a strong undefined heritable component. Two recent independent
cardiovascular SNP array studies identified a common SNP at 1p36 in intron 2 of the …
cardiovascular SNP array studies identified a common SNP at 1p36 in intron 2 of the …