User profiles for Debashis Sahoo

Debashis Sahoo

Associate Professor of Pediatrics and Computer Science, University of California San Diego
Verified email at ucsd.edu
Cited by 11813

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

…, JP Volkmer, AJ Gentles, D Sahoo… - Proceedings of the …, 2012 - National Acad Sciences
CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

Single-cell dissection of transcriptional heterogeneity in human colon tumors

P Dalerba, T Kalisky, D Sahoo, PS Rajendran… - Nature …, 2011 - nature.com
Cancer is often viewed as a caricature of normal developmental processes, but the extent to
which its cellular heterogeneity truly recapitulates multilineage differentiation processes of …

[PDF][PDF] Identification of the human skeletal stem cell

…, T Siebel, K Chan, K Schallmoser, J Seita, D Sahoo… - Cell, 2018 - cell.com
Stem cell regulation and hierarchical organization of human skeletal progenitors remain
largely unexplored. Here, we report the isolation of a self-renewing and multipotent human …

Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1

…, JE Baik, SM Lagana, RP Han, WJ Raab, D Sahoo… - EMBO …, 2019 - embopress.org
Fusobacterium nucleatum, a Gram‐negative oral anaerobe, is a significant contributor to
colorectal cancer. Using an in vitro cancer progression model, we discover that F. nucleatum …

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

WW Pang, EA Price, D Sahoo… - Proceedings of the …, 2011 - National Acad Sciences
In the human hematopoietic system, aging is associated with decreased bone marrow
cellularity, decreased adaptive immune system function, and increased incidence of anemia and …

[HTML][HTML] Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis

CH Wu, D Sahoo, C Arvanitis, N Bradon, DL Dill… - PLoS …, 2008 - journals.plos.org
The MYC oncogene has been implicated in the regulation of up to thousands of genes
involved in many cellular programs including proliferation, growth, differentiation, self-renewal, …

[HTML][HTML] Identification and specification of the mouse skeletal stem cell

…, KS Yan, R Upton, GG Walmsley, AS Lee, D Sahoo… - Cell, 2015 - cell.com
How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage,
and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse …

[HTML][HTML] CDX2 as a prognostic biomarker in stage II and stage III colon cancer

P Dalerba, D Sahoo, S Paik, X Guo… - … England Journal of …, 2016 - Mass Medical Soc
Background The identification of high-risk stage II colon cancers is key to the selection of
patients who require adjuvant treatment after surgery. Microarray-based multigene-expression …

Aged skeletal stem cells generate an inflammatory degenerative niche

…, SD Conley, J Seita, M Morri, NF Neff, D Sahoo… - Nature, 2021 - nature.com
Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts 1 . Here we show that intrinsic ageing of …

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells

C Tang, AS Lee, JP Volkmer, D Sahoo, D Nag… - Nature …, 2011 - nature.com
An important risk in the clinical application of human pluripotent stem cells (hPSCs), including
human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is teratoma …