Aniridia is a semidominant disorder in which development of the iris, lens, cornea and retina
is disturbed. The mouse mutation Small eye (Sey), which has been proposed as a model for …

Vertebrate Pax proteins share a conserved 128-amino-acid DNA-binding motif, the paired
domain. The PAX6 gene, which is mutated in the murine Small eye and human aniridia …

Tamoxifen is currently the first-line therapy for treatment of hormone-dependent breast cancer.
However, despite initial benefits, most patients eventually relapse. Two groups of patients …

Primary angle-closure glaucoma is a major cause of blindness worldwide. It is a disease of
ocular anatomy that is related to pupillary-block and angle-crowding mechanisms of filtration …

The cloning of a second estrogen receptor (ER), ERβ, has prompted a reevaluation of the role
of ERs in breast cancer. The aim of this study was to determine the expression of both ER …

Aniridia is a rare hereditary bilateral panocular disorder that is associated with glaucoma and
the PAX6 gene. It is characterized by an apparent congenital deficiency of iris tissue. 1 The …

… Grant and Walton than in the other, as is often the case in aniridia, we would do the prophylactic
… Also, I know Dr Walton very well and am familiar with this work. I must say I am therefore …

Aniridia is a panocular human eye malformation caused by heterozygous null mutations
within PAX6, a paired-box transcription factor, or cytogenetic deletions of chromosome 11p13 …

Educational Objectives 1. To review current and new information of clinical value related to
primary congenital glaucoma, including its genetic etiology, defining clinical features, and …

To assess the use of drainage implants in pediatric patients with glaucoma refractory to
conventional medical and surgical therapy, we retrospectively reviewed 20 consecutive eyes in …