Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the
two conditions do not always coincide and the molecular determinants of "healthy" versus "…

The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved
proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans …

It is becoming more and more accepted that, in addition to producing autoantibodies, B
lymphocytes have other important functions that influence the development of autoimmunity. For …

Hyper-IgE syndromes comprise a group of inborn errors of immunity. STAT3-deficient hyper-IgE
syndrome is characterized by elevated serum IgE levels, recurrent infections and …

Immune responses need to be controlled tightly to prevent autoimmune diseases, yet
underlying molecular mechanisms remain partially understood. Here, we identify biallelic …

The WAVE regulatory complex (WRC) is crucial for assembly of the peripheral branched actin
network constituting one of the main drivers of eukaryotic cell migration. Here, we uncover …

Dysregulated immune responses are essential underlying causes of a plethora of pathologies
including cancer, autoimmunity, and immunodeficiency. We here investigated 4 patients …

Developing pre-B cells in the bone marrow alternate between proliferation and differentiation
phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell …

Tyrosine phosphorylation of signaling molecules that mediate B cell activation in response
to various stimuli is tightly regulated by protein tyrosine phosphatases (PTPs). PTP1B is a …

Signal transduction from the BCR is regulated by the equilibrium between kinases (eg, spleen
tyrosine kinase [Syk]) and phosphatases (eg, Shp-1). Previous studies showed that Syk-…