User profiles for Daniel S Ory
Daniel OryChief Medical Officer, Arbor Bio Verified email at arbor.bio Cited by 26234 |
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
…, S Cases, RV Farese Jr, DS Ory… - Proceedings of the …, 2003 - National Acad Sciences
Excess lipid accumulation in non-adipose tissues is associated with insulin resistance,
pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the …
pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the …
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.
DS Ory, BA Neugeboren… - Proceedings of the …, 1996 - National Acad Sciences
We have generated a human 293-derived retroviral packaging cell line (293GPG) capable
of producing high titers of recombinant Moloney murine leukemia virus particles that have …
of producing high titers of recombinant Moloney murine leukemia virus particles that have …
[HTML][HTML] Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
Cell dysfunction and death induced by lipid accumulation in nonadipose tissues, or
lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the …
lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the …
[HTML][HTML] Palmitate-induced apoptosis can occur through a ceramide-independent pathway
LL Listenberger, DS Ory, JE Schaffer - Journal of Biological Chemistry, 2001 - ASBMB
Cytotoxic accumulation of long chain fatty acids has been proposed to play an important role
in the pathogenesis of diabetes mellitus and heart disease. To explore the mechanism of …
in the pathogenesis of diabetes mellitus and heart disease. To explore the mechanism of …
miR-33 links SREBP-2 induction to repression of sterol transporters
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR)
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
…, TL Sharp, N Sambandam, KM Olson, DS Ory… - Circulation …, 2005 - Am Heart Assoc
Evidence is emerging that systemic metabolic disturbances contribute to cardiac myocyte
dysfunction and clinically apparent heart failure, independent of associated coronary artery …
dysfunction and clinically apparent heart failure, independent of associated coronary artery …
[HTML][HTML] Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression
…, G Stephney, S Renault, K Dobrenis, DS Ory… - PloS one, 2009 - journals.plos.org
Background Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder
caused most commonly by a defect in the NPC1 protein and characterized by widespread …
caused most commonly by a defect in the NPC1 protein and characterized by widespread …
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that becomes activated at the lysosome in response to nutrient cues. Here, we …
regulator that becomes activated at the lysosome in response to nutrient cues. Here, we …
[HTML][HTML] Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells
…, L Chaudhary, A Fausto, LR Halstead, DS Ory… - Journal of Biological …, 2001 - ASBMB
Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein kinase
superfamily, play an important role in cell proliferation and differentiation. In this study we …
superfamily, play an important role in cell proliferation and differentiation. In this study we …
Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease
Niemann-Pick type C1 (NPC1) disease is a rare progressive neurodegenerative disorder
characterized by accumulation of cholesterol in the endolysosomes. Previous studies …
characterized by accumulation of cholesterol in the endolysosomes. Previous studies …