User profiles for Daniel S Ory

Daniel Ory

Chief Medical Officer, Arbor Bio
Verified email at arbor.bio
Cited by 26234

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

…, S Cases, RV Farese Jr, DS Ory… - Proceedings of the …, 2003 - National Acad Sciences
Excess lipid accumulation in non-adipose tissues is associated with insulin resistance,
pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the …

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

DS Ory, BA Neugeboren… - Proceedings of the …, 1996 - National Acad Sciences
We have generated a human 293-derived retroviral packaging cell line (293GPG) capable
of producing high titers of recombinant Moloney murine leukemia virus particles that have …

[HTML][HTML] Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

NM Borradaile, X Han, JD Harp, SE Gale, DS Ory… - Journal of lipid …, 2006 - ASBMB
Cell dysfunction and death induced by lipid accumulation in nonadipose tissues, or
lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the …

[HTML][HTML] Palmitate-induced apoptosis can occur through a ceramide-independent pathway

LL Listenberger, DS Ory, JE Schaffer - Journal of Biological Chemistry, 2001 - ASBMB
Cytotoxic accumulation of long chain fatty acids has been proposed to play an important role
in the pathogenesis of diabetes mellitus and heart disease. To explore the mechanism of …

miR-33 links SREBP-2 induction to repression of sterol transporters

TJ Marquart, RM Allen, DS Ory… - Proceedings of the …, 2010 - National Acad Sciences
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR)
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …

Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy

…, TL Sharp, N Sambandam, KM Olson, DS Ory… - Circulation …, 2005 - Am Heart Assoc
Evidence is emerging that systemic metabolic disturbances contribute to cardiac myocyte
dysfunction and clinically apparent heart failure, independent of associated coronary artery …

[HTML][HTML] Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression

…, G Stephney, S Renault, K Dobrenis, DS Ory… - PloS one, 2009 - journals.plos.org
Background Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder
caused most commonly by a defect in the NPC1 protein and characterized by widespread …

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

…, SM Louie, RM Perera, DF Covey, DK Nomura, DS Ory… - Science, 2017 - science.org
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that becomes activated at the lysosome in response to nutrient cues. Here, we …

[HTML][HTML] Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells

…, L Chaudhary, A Fausto, LR Halstead, DS Ory… - Journal of Biological …, 2001 - ASBMB
Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein kinase
superfamily, play an important role in cell proliferation and differentiation. In this study we …

Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease

…, J House, C Vite, JE Schaffer, DS Ory - Science translational …, 2010 - science.org
Niemann-Pick type C1 (NPC1) disease is a rare progressive neurodegenerative disorder
characterized by accumulation of cholesterol in the endolysosomes. Previous studies …