Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

Background Detailed neuropathological information on the structural brain lesions underlying
seizures is valuable for understanding drug-resistant focal epilepsy. Methods We report …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

… Further information and requests for resources, raw data, and reagents should be
directed and will be fulfilled by the Contact: DH Heiland, dieter.henrik.heiland@uniklinik-freiburg.de. …

The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-…

Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses
and contribute to several neurological and psychiatric diseases. Little is known about …

The innate immune compartment of the human central nervous system (CNS) is highly diverse
and includes several immune-cell populations such as macrophages that are frequent in …

Intraoperative histopathological examinations are routinely performed to provide
neurosurgeons with information about the entity of tumor tissue. Here, we quantified the …

PURPOSE Clinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably
heterogeneous, yet identification of patients at high risk for treatment failure is challenging. …

Histopathological diagnosis is the current standard for the classification of brain and spine
tumors. Raman spectroscopy has been reported to allow fast and easy intraoperative tissue …