Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

…, M Davieau, A Mollé, A Sadek, C Fourgeux… - Nature …, 2020 - nature.com
Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired
pneumonia. As phagocytosis by macrophages plays a critical role in the control of bacteria, we …

Rotavirus anti-VP6 secretory immunoglobulin A contributes to protection via intracellular neutralization but not via immune exclusion

B Corthésy, Y Benureau, C Perrier, C Fourgeux… - Journal of …, 2006 - Am Soc Microbiol
Immunoglobulin A (IgA) monoclonal antibodies (MAbs) directed at the conserved inner core
protein VP6 of rotavirus, such as the IgA7D9 MAb, provide protective immunity in adult and …

CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy

…, C Ligeron, I Girault, MD Lopez, C Fourgeux… - Science …, 2022 - science.org
Tumors exploit numerous immune checkpoints, including those deployed by myeloid cells to
curtail antitumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed …

Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection

N Parez, C Fourgeux, A Mohamed… - Journal of …, 2006 - Am Soc Microbiol
To evaluate whether the rectal route of immunization may be used to provide appropriate
protection against enteric pathogens such as rotaviruses (RV), we studied the antibody …

[HTML][HTML] Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

C Fourgeux, L Martine, I Björkhem… - … & visual science, 2009 - tvst.arvojournals.org
Purpose.: Genetics has made significant contributions to the study of glaucoma over the
past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing …

Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model

…, MA Maire, B Pasquis, S Grégoire, C Fourgeux… - Graefe's Archive for …, 2008 - Springer
Background The aim of this study was to set up an animal model of dry eye showing disturbance
in several components of the lacrimal functional unit, and to describe the time course of …

[PDF][PDF] Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder

…, M Vincent, A Mollé, OA Adebambo, C Fourgeux… - The American Journal of …, 2021 - cell.com
Proteins involved in transcriptional regulation harbor a demonstrated enrichment of mutations
in neurodevelopmental disorders. The Sin3 (Swi-independent 3)/histone deacetylase (…

Dendritic cells require TMEM176A/B ion channels for optimal MHC class II antigen presentation to naive CD4+ T cells

…, A Even, A Moreau, A Molle, C Fourgeux… - The Journal of …, 2021 - journals.aai.org
Intracellular ion fluxes emerge as critical actors of immunoregulation but still remain poorly
explored. In this study, we investigated the role of the redundant cation channels TMEM176A …

Monocyte signature associated with herpes simplex virus reactivation and neurological recovery after brain injury

…, P Solomon, L Castain, C Fourgeux… - American Journal of …, 2022 - atsjournals.org
Rationale: Brain injury induces systemic immunosuppression, increasing the risk of viral
reactivations and altering neurological recovery. Objectives: To determine if systemic immune …

Steady‐state levels of retinal 24S‐hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat

C Fourgeux, L Martine, B Pasquis… - Acta …, 2012 - Wiley Online Library
Purpose: Our previous studies suggested that CYP46A1 and 24S‐hydroxycholesterol (24SOH)
may be associated with glaucoma. Loss of CYP46A1‐expressing retinal ganglion cells is …