It is well known that mitochondrial damage (MD) is both the major contributor to oxidative
stress (OS) (the condition arising from unbalance between production and removal of reactive …

Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and
from models based on the overexpression of mutant SOD1 found in a small subset of patients, …

The NAD + -dependent deacetylase protein Sirtuin 3 (SIRT3) is emerging among the factors
playing a key role in the regulation of mitochondrial function and in the prevention of …

Vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS) arises from a combination
of several mechanisms, including protein misfolding and aggregation, mitochondrial …

A laboratory strain of Schistosoma mansoni subjected to repeated in vivo praziquantel (PZQ)
treatments for several generations has been previously found to have lesser sensitivity to …

Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson’s disease (PD).
Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. …

Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …

Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a “non-cell autonomous”
process, with astrocytes playing a critical role in disease progression. Glial cells are …

The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of
calcium into the worms, suggesting that this phenomenon could be the source of the observed …

Amyotrophic lateral sclerosis is characterized by the degeneration of upper and lower motor
neurons, yet an increasing number of studies in both mouse models and patients with …