User profiles for Cornelius Y Taabazuing
 | Cornelius TaabazuingUniversity of Pennsylvania Perelman School of Medicine Verified email at pennmedicine.upenn.edu Cited by 1858 |
[PDF][PDF] Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages
CY Taabazuing, MC Okondo, DA Bachovchin - Cell chemical biology, 2017 - cell.com
Pyroptosis is a lytic form of programmed cell death mediated by the inflammatory caspase-1,
-4, and -5. We recently discovered that small-molecule inhibitors of the serine peptidases …
-4, and -5. We recently discovered that small-molecule inhibitors of the serine peptidases …
N-terminal degradation activates the NLRP1B inflammasome
Intracellular pathogens and danger signals trigger the formation of inflammasomes, which
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …
DPP9's enzymatic activity and not its binding to CARD8 inhibits inflammasome activation
…, AJ Chui, SD Rao, CY Taabazuing… - ACS Chemical …, 2019 - ACS Publications
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and
CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) …
CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) …
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
DC Johnson, CY Taabazuing, MC Okondo, AJ Chui… - Nature medicine, 2018 - nature.com
Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …
The NLRP1 and CARD8 inflammasomes
CY Taabazuing, AR Griswold… - Immunological …, 2020 - Wiley Online Library
Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …
[PDF][PDF] Inhibition of Dpp8/9 activates the Nlrp1b inflammasome
MC Okondo, SD Rao, CY Taabazuing, AJ Chui… - Cell chemical …, 2018 - cell.com
Val-boroPro (PT-100, Talabostat) induces powerful anti-tumor immune responses in syngeneic
cancer models, but its mechanism of action has not yet been established. Val-boroPro is …
cancer models, but its mechanism of action has not yet been established. Val-boroPro is …
Caspase-1 interdomain linker cleavage is required for pyroptosis
Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs)
to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell …
to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell …
Substrate promotes productive gas binding in the α-ketoglutarate-dependent oxygenase FIH
The Fe 2+ /α-ketoglutarate (αKG)-dependent oxygenases use molecular oxygen to conduct
a wide variety of reactions with important biological implications, such as DNA base excision …
a wide variety of reactions with important biological implications, such as DNA base excision …
[PDF][PDF] Activation of the CARD8 inflammasome requires a disordered region
AJ Chui, AR Griswold, CY Taabazuing, EL Orth, K Gai… - Cell reports, 2020 - cell.com
Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called
canonical inflammasomes in response to intracellular danger signals. Canonical …
canonical inflammasomes in response to intracellular danger signals. Canonical …
Oxygen sensing strategies in mammals and bacteria
The ability to sense and adapt to changes in pO 2 is crucial for basic metabolism in most
organisms, leading to elaborate pathways for sensing hypoxia (low pO 2 ). This review focuses …
organisms, leading to elaborate pathways for sensing hypoxia (low pO 2 ). This review focuses …