Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
…, A Stenzinger, A Schillert, V Vogel, C Klein… - Nature …, 2013 - nature.com
It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of …
circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of …
[PDF][PDF] Radial glia serve as neuronal progenitors in all regions of the central nervous system
Radial glial cells function during CNS development as neural progenitors, although their
precise contribution to neurogenesis remains controversial. Recent work has argued that …
precise contribution to neurogenesis remains controversial. Recent work has argued that …
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
…, I Bayindir, P Kaschutnig, K Muedder, C Klein… - Nature, 2015 - nature.com
Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells.
The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major …
The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major …
[PDF][PDF] Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit
…, A Lier, C Eisen, V Nowak, B Zens, K Müdder, C Klein… - Cell stem cell, 2014 - cell.com
Myelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with
defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche. …
defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche. …
[HTML][HTML] MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome
in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an …
in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an …
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau
C Klein, EM Krämer, AM Cardine… - Journal of …, 2002 - Soc Neuroscience
Fyn kinase plays an important role during myelination and has been shown to promote
morphological differentiation of cultured oligodendrocytes. We analyzed the downstream targets …
morphological differentiation of cultured oligodendrocytes. We analyzed the downstream targets …
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma
…, A Stenzinger, E Espinet, A Muckenhuber, C Klein… - Nature medicine, 2016 - nature.com
Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this
malignancy is clinically still treated as a single disease. Here we present patient-derived …
malignancy is clinically still treated as a single disease. Here we present patient-derived …
[HTML][HTML] Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination
EM Krämer, C Klein, T Koch, M Boytinck… - Journal of Biological …, 1999 - ASBMB
In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in
detergent-resistant membrane rafts. These are plasma membrane microdomains enriched …
detergent-resistant membrane rafts. These are plasma membrane microdomains enriched …
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
…, H Röhl, SH Witt, H Dukal, C Klein… - Blood, The Journal …, 2016 - ashpublications.org
Clonal evolution is believed to be a main driver for progression of various types of cancer
and implicated in facilitating resistance to drugs. However, the hierarchical organization of …
and implicated in facilitating resistance to drugs. However, the hierarchical organization of …
Gene expression in cortical interneuron precursors is prescient of their mature function
At present little is known about the developmental mechanisms that give rise to inhibitory γ-aminobutyric
acidergic interneurons of the neocortex or the timing of their subtype …
acidergic interneurons of the neocortex or the timing of their subtype …