It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of …

Radial glial cells function during CNS development as neural progenitors, although their
precise contribution to neurogenesis remains controversial. Recent work has argued that …

Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells.
The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major …

Myelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with
defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche. …

Aberrant expression of MYC transcription factor family members predicts poor clinical outcome
in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an …

Fyn kinase plays an important role during myelination and has been shown to promote
morphological differentiation of cultured oligodendrocytes. We analyzed the downstream targets …

Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this
malignancy is clinically still treated as a single disease. Here we present patient-derived …

In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in
detergent-resistant membrane rafts. These are plasma membrane microdomains enriched …

Clonal evolution is believed to be a main driver for progression of various types of cancer
and implicated in facilitating resistance to drugs. However, the hierarchical organization of …

At present little is known about the developmental mechanisms that give rise to inhibitory γ-aminobutyric
acidergic interneurons of the neocortex or the timing of their subtype …