IntAct is an open source database and software suite for modeling, storing and analyzing
molecular interaction data. The data available in the database originates entirely from …

Abstract Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target
the BRAF or MEK kinases can be effective, but resistance develops invariably 1 , 2 . In …

Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive
malignancy with few effective treatment options 1 . Lenvatinib is a small-molecule inhibitor of …

There are no effective therapies for the ∼30% of human malignancies with mutant RAS
oncogenes. Using a kinome-centered synthetic lethality screen, we find that suppression of the …

Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through
antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-…

Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies
1 , 2 ; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit …

RAS mutations are frequent in human cancer, especially in pancreatic, colorectal and non-small-cell
lung cancers (NSCLCs) 1 , 2 – 3 . Inhibition of the RAS oncoproteins has proven …

The dependency of cancer cells on glutamine may be exploited therapeutically as a new
strategy for treating cancers that lack druggable driver genes. Here we found that human liver …

Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but
BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback …

Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells
can also undergo senescence, but the stresses that provoke cancer cells to undergo …