10.7554/eLife.47246.001 Cytoplasmic dynein plays critical roles within the developing and
mature nervous systems, including effecting nuclear migration, and retrograde transport of …

Dynamic instability is an intrinsic property of microtubules; however, we do not understand
what domains of αβ-tubulins regulate this activity or how these regulate microtubule networks …

EB1 was discovered 25 years ago as a binding partner of the tumor suppressor adenomatous
polyposis coli (APC) [1]; however, the significance of EB1-APC interactions has remained …

How dynein motors accurately move cargoes is an important question. In budding yeast,
dynein moves the mitotic spindle to the predetermined site of cytokinesis by pulling on astral …

Dynamic microtubules are fundamental to many cellular processes, and accurate measurements
of microtubule dynamics can provide insight into how cells regulate these processes …

How microtubules transition from depolymerization to polymerization, known as rescue, is
poorly understood. Here we examine two models for rescue: 1) an “end-driven” model in …

We report a new step in the fertilization in Xenopus laevis which has been found to involve
activation of Src tyrosine kinase to stimulate phospholipase C-γ (PLC-γ) which increases …

Despite the broadly conserved role of microtubules in chromosome segregation, we have a
limited understanding of how molecular features of tubulin proteins contribute to the …

During Xenopus fertilization, the initial intracellular calcium ((Ca 2+ ) i ) release at the sperm-egg
binding site (hot spot) has not been described without the use of inhibitors, nor related …

… During the time period for our study, Medicare fees were reduced by only 1.2 percent to
account for the behavioral response (Colby 1992) and were about 61 percent of private payers’ …