The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Glaucoma is a leading cause of irreversible blindness. A genome-wide search yielded multiple
single-nucleotide polymorphisms (SNPs) in the 15q24.1 region associated with glaucoma…

Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM
153700), is an autosomal dominant form of macular degeneration characterized by an …

We report a novel combination of factors that explains almost 60% of variable response to
warfarin. Warfarin is a widely used anticoagulant, which acts through interference with vitamin …

We report an extensive study of variability in genes encoding proteins that are believed to be
involved in the action and biotransformation of warfarin. Warfarin is a commonly prescribed …

We conducted a genome-wide association study for primary open-angle glaucoma (POAG)
in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a …

The genomes of higher organisms are packaged in nucleosomes with functional histone
modifications. Until now, genome-wide nucleosome and histone modification studies have …

Motivation: Pre-selection of informative features for supervised classification is a crucial,
albeit delicate, task. It is desirable that feature selection provides the features that contribute …

Background— Fixed-dose unmonitored treatment with dabigatran etexilate is effective and
has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared …