Proteins are essential agents of biological processes. To date, large-scale profiling of cell line
collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily on …

In the last decade, single-cell RNA sequencing routinely performed on large numbers of single
cells has greatly advanced our understanding of the underlying heterogeneity of complex …

Single-cell proteomics by mass spectrometry (SCoPE-MS) is a recently introduced method
to quantify multiplexed single-cell proteomes. While this technique has generated great …

Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small
molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed …

The pore-forming protein gasdermin D (GSDMD) executes lytic cell death called pyroptosis
to eliminate the replicative niche of intracellular pathogens. Evolution favors pathogens that …

Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate the …

System-wide quantitative analysis of ubiquitylomes has proven to be a valuable tool for
elucidating targets and mechanisms of the ubiquitin-driven signaling systems, as well as gaining …

Blood was collected at intervals during a 24-hour period from 23 healthy male volunteers on
diets containing various amounts of protein; the plasma was assayed for 16 amino acids. …

Targeted mass spectrometry assays for protein quantitation monitor peptide surrogates, which
are easily multiplexed to target many peptides in a single assay. However, these assays …