Over the last 25 years, more than a hundred dictator game experiments have been published.
This meta study summarises the evidence. Exploiting the fact that most experiments had to …

Objective To determine the prevalence and mortality of ICU patients with severe sepsis in
Germany, with consideration of hospital size. Design Prospective, observational, cross-…

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Successful solutions to pressing social ills tend to consist of innovative combinations of a
limited set of alternative ways of perceiving and resolving the issues. These contending policy …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

Background The role of intensive insulin therapy in patients with severe sepsis is uncertain.
Fluid resuscitation improves survival among patients with septic shock, but evidence is …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Germline mutations in a number of genes involved in the recombinational repair of DNA
double-strand breaks are associated with predisposition to breast and ovarian cancer. RAD51C …

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …

Background: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome,
which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is …