Long-lived memory CD8 + T cells play important roles in tumor immunity. Studies over the
past two decades have identified four subsets of memory CD8 + T cells - central, effector, stem-…

Tissue-resident memory T (T RM ) cells have been widely characterized in infectious disease
settings; however, their role in mediating immunity to cancer remains unknown. We report …

While T-cell responses to cancer immunotherapy have been avidly studied, long-lived
memory has been poorly characterized. In a cohort of metastatic melanoma survivors with …

The nature of the anti-tumor immune response changes as primary tumors progress and
metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) …

Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling.
Whether this signaling pathway regulates the tumor microenvironment has remained …

We explored diverse alterations contributing to liposarcomagenesis by sequencing the
genome, exome, transcriptome, and cytosine methylome of a primary and recurrent …

Merkel cell carcinoma (MCC) is an aggressive form of skin cancer which, while chemosensitive,
has high rates of relapse and chemoresistance, limiting the impact of chemotherapy. An …

Acquired resistance to BRAF V600E inhibitors (BRAFi) in melanoma remains a common
clinical obstacle, as is the case for any targeted drug therapy that can be developed given the …

Liposarcomas are the most common type of soft tissue sarcoma but their genetics are poorly
defined. To identify genes that contribute to liposarcomagenesis and serve as prognostic …

Adaptive immune responses contribute to the pathogenesis of melanoma by facilitating
immune evasion. V-domain Ig suppressor of T-cell activation (VISTA) is a potent negative …