Signalling downstream of activated mammalian Notch
NOTCH belongs to a family of transmembrane proteins that are widely conserved from flies
to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the …
to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the …
[PDF][PDF] A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
C Brou, F Logeat, N Gupta, C Bessia, O LeBail… - Molecular cell, 2000 - cell.com
The Notch1 receptor is presented at the cell membrane as a heterodimer after constitutive
processing by a furin-like convertase. Ligand binding induces the proteolytic release of Notch …
processing by a furin-like convertase. Ligand binding induces the proteolytic release of Notch …
The human estrogen receptor has two independent nonacidic transcriptional activation functions
Wehave~ fousfymportedthefnesenceotahonnoneinducible transcriptional activation function
(TAPP) within the region of the estrogen receptor (ER) that contains the hormone binding …
(TAPP) within the region of the estrogen receptor (ER) that contains the hormone binding …
The Notch1 receptor is cleaved constitutively by a furin-like convertase
F Logeat, C Bessia, C Brou, O LeBail… - Proceedings of the …, 1998 - National Acad Sciences
The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and
vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that …
vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that …
[HTML][HTML] Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
N Gupta-Rossi, O Le Bail, H Gonen, C Brou… - Journal of Biological …, 2001 - ASBMB
The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well
as in vertebrates. After ligand binding, a two-step proteolytic cleavage releases the …
as in vertebrates. After ligand binding, a two-step proteolytic cleavage releases the …
Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation
…, O Pourquié, F Logeat, CF Strong, C Brou… - … and cellular biology, 1998 - Taylor & Francis
The Notch receptor is involved in many cell fate determination events in vertebrates and
invertebrates. It has been shown in Drosophila melanogaster that Delta-dependent Notch …
invertebrates. It has been shown in Drosophila melanogaster that Delta-dependent Notch …
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
E Six, D Ndiaye, Y Laâbi, C Brou… - Proceedings of the …, 2003 - National Acad Sciences
Notch signaling is involved in numerous cell fate decisions in invertebrates and vertebrates.
The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic …
The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic …
Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
…, P Chastagner, A Olry, A Israël, C Brou - The Journal of cell …, 2004 - rupress.org
Activation of mammalian Notch receptor by its ligands induces TNFα-converting enzyme–dependent
ectodomain shedding, followed by intramembrane proteolysis due to presenilin (PS)…
ectodomain shedding, followed by intramembrane proteolysis due to presenilin (PS)…
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor
X Jacq, C Brou, Y Lutz, I Davidson, P Chambon, L Tora - Cell, 1994 - cell.com
We showed previously that coactivators mediating stimulation by different activators were
associated with the TATA-binding protein (TBP) in distinct TFIID complexes. We have …
associated with the TATA-binding protein (TBP) in distinct TFIID complexes. We have …
Itch/AIP4 mediates Deltex degradation through the formation of K29‐linked polyubiquitin chains
P Chastagner, A Israël, C Brou - EMBO reports, 2006 - embopress.org
Deltex (DTX) and AIP4 are the human orthologues of the Drosophila deltex and Suppressor
of deltex, which have been genetically described as being antagonistically involved in the …
of deltex, which have been genetically described as being antagonistically involved in the …