User profiles for Carsten Janke

Carsten Janke

Institut Curie
Verified email at curie.fr
Cited by 14004

The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity, …

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

C Janke, J Chloë Bulinski - Nature reviews Molecular cell biology, 2011 - nature.com
Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However, …

[PDF][PDF] Causes and consequences of microtubule acetylation

C Janke, G Montagnac - Current Biology, 2017 - cell.com
Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) …

The tubulin code: molecular components, readout mechanisms, and functions

C Janke - Journal of Cell Biology, 2014 - rupress.org
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the …

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

C Janke, K Rogowski, D Wloga, C Regnard, AV Kajava… - Science, 2005 - science.org
Polyglutamylation of tubulin has been implicated in several functions of microtubules, but
the identification of the responsible enzyme(s) has been challenging. We found that the …

Microtubule detyrosination guides chromosomes during mitosis

…, MM Magiera, AV Zaytsev, AL Pereira, C Janke… - Science, 2015 - science.org
Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator,
a process known as chromosome congression. Centromere-associated protein E (CENP-E)/…

A versatile toolbox for PCR‐based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes

C Janke, MM Magiera, N Rathfelder, C Taxis, S Reber… - Yeast, 2004 - Wiley Online Library
Tagging of genes by chromosomal integration of PCR amplified cassettes is a widely used
and fast method to label proteins in vivo in the yeast Saccharomyces cerevisiae. This strategy …

[HTML][HTML] Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

TU Tanaka, N Rachidi, C Janke, G Pereira, M Galova… - Cell, 2002 - cell.com
How sister kinetochores attach to microtubules from opposite spindle poles during mitosis (bi-orientation)
remains poorly understood. In yeast, the ortholog of the Aurora B-INCENP …

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon

…, JP Medema, I Bičche, M Hahne, C Janke - The EMBO …, 2014 - embopress.org
TTLL 3 and TTLL 8 are tubulin glycine ligases catalyzing posttranslational glycylation of
microtubules. We show here for the first time that these enzymes are required for robust …

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

C Janke, M Kneussel - Trends in neurosciences, 2010 - cell.com
In the past decades, a range of post-translational modifications has been discovered on
tubulins, the major constituents of microtubules. Pioneering studies have described the …