User profiles for Carsten Janke
Carsten JankeInstitut Curie Verified email at curie.fr Cited by 14004 |
The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity, …
division, shaping, motility and intracellular transport. Despite their functional heterogeneity, …
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
C Janke, J Chloë Bulinski - Nature reviews Molecular cell biology, 2011 - nature.com
Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However, …
that may explain the diverse functions of microtubules within cells and organisms. However, …
[PDF][PDF] Causes and consequences of microtubule acetylation
C Janke, G Montagnac - Current Biology, 2017 - cell.com
Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) …
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) …
The tubulin code: molecular components, readout mechanisms, and functions
C Janke - Journal of Cell Biology, 2014 - rupress.org
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the …
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the …
Tubulin polyglutamylase enzymes are members of the TTL domain protein family
Polyglutamylation of tubulin has been implicated in several functions of microtubules, but
the identification of the responsible enzyme(s) has been challenging. We found that the …
the identification of the responsible enzyme(s) has been challenging. We found that the …
Microtubule detyrosination guides chromosomes during mitosis
…, MM Magiera, AV Zaytsev, AL Pereira, C Janke… - Science, 2015 - science.org
Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator,
a process known as chromosome congression. Centromere-associated protein E (CENP-E)/…
a process known as chromosome congression. Centromere-associated protein E (CENP-E)/…
A versatile toolbox for PCR‐based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes
Tagging of genes by chromosomal integration of PCR amplified cassettes is a widely used
and fast method to label proteins in vivo in the yeast Saccharomyces cerevisiae. This strategy …
and fast method to label proteins in vivo in the yeast Saccharomyces cerevisiae. This strategy …
[HTML][HTML] Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
How sister kinetochores attach to microtubules from opposite spindle poles during mitosis (bi-orientation)
remains poorly understood. In yeast, the ortholog of the Aurora B-INCENP …
remains poorly understood. In yeast, the ortholog of the Aurora B-INCENP …
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon
TTLL 3 and TTLL 8 are tubulin glycine ligases catalyzing posttranslational glycylation of
microtubules. We show here for the first time that these enzymes are required for robust …
microtubules. We show here for the first time that these enzymes are required for robust …
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
C Janke, M Kneussel - Trends in neurosciences, 2010 - cell.com
In the past decades, a range of post-translational modifications has been discovered on
tubulins, the major constituents of microtubules. Pioneering studies have described the …
tubulins, the major constituents of microtubules. Pioneering studies have described the …