[HTML][HTML] Fibroblasts in fibrosis: novel roles and mediators

RT Kendall, CA Feghali-Bostwick - Frontiers in pharmacology, 2014 - frontiersin.org
Fibroblasts are the most common cell type of the connective tissues found throughout the body
and the principal source of the extensive extracellular matrix (ECM) characteristic of these …

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

…, LE Fredenburgh, C Feghali-Bostwick… - … of Physiology-Lung …, 2015 - journals.physiology.org
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …

[HTML][HTML] Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease

…, HP Kim, FC Sciurba, SJ Lee, C Feghali-Bostwick… - PloS one, 2008 - journals.plos.org
Background Chronic obstructive pulmonary disease (COPD) is a progressive lung disease
characterized by abnormal cellular responses to cigarette smoke, resulting in tissue …

Partial inhibition of integrin αvβ6 prevents pulmonary fibrosis without exacerbating inflammation

…, NJ Rinaldi, J Goyal, CA Feghali-Bostwick… - American journal of …, 2008 - atsjournals.org
Rationale: Transforming growth factor (TGF)-β has a central role in driving many of the
pathological processes that characterize pulmonary fibrosis. Inhibition of the integrin αvβ6, a key …

Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies

C FeghaliBostwick, TA Medsger Jr… - Arthritis & Rheumatism …, 2003 - Wiley Online Library
Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance
for the presence of antinuclear antibodies - FeghaliBostwick - 2003 - Arthritis & …

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis

…, HP Kim, Z Zhou, CA Feghali-Bostwick… - The Journal of …, 2006 - rupress.org
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by
activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1), a …

Autoantibodies in patients with chronic obstructive pulmonary disease

CA Feghali-Bostwick, AS Gadgil… - American journal of …, 2008 - atsjournals.org
Rationale: Adaptive immune responses are present in patients with chronic obstructive
pulmonary disease (COPD), and it has been postulated that these processes could be …

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

…, N Kaminski, CA Feghali-Bostwick… - Proceedings of the …, 2004 - National Acad Sciences
To better understand the molecular basis of chronic obstructive pulmonary disease (COPD),
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …

[HTML][HTML] Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling

…, A Zirk, J Eisenbart, C Feghali-Bostwick… - Journal of Biological …, 2013 - ASBMB
TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling
can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-β …

[HTML][HTML] Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma

…, R Lafyatis, T Radstake, C Feghali-Bostwick… - The American journal of …, 2013 - Elsevier
Because recent studies implicate Toll-like receptors (TLRs) in the pathogenesis of fibrosis,
we sought to investigate the in vitro and in vivo role and mechanism of TLR4-mediated …