Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular
dystrophy and occurs in 1 in 3500 male births. Improved survival due to improvements in clinical …

Recent studies showed that chronic administration of losartan, an angiotensin II type I receptor
antagonist, improved skeletal muscle function in dystrophin-deficient mdx mice. In this …

Antisense oligonucleotide-mediated exon skipping is able to correct out-of-frame mutations
in Duchenne muscular dystrophy and restore truncated yet functional dystrophins. However, …

Muscular Dystrophy, convened a Working Group meeting on July 2014, in Bethesda, MD, to
explore clinical and research questions related to cardiac disease in patients with DMD. As …

Background— There is a lack of clear diagnostic and management guidelines for acute
myocarditis in the pediatric population. We used a multi-institutional database to characterize …

The availability of animal models for Duchenne muscular dystrophy has led to extensive
preclinical research on potential therapeutics. Few studies have focused on reliability and …

… Spurney, MD, is an associate professor of Pediatrics in the Division of Cardiology and the
Center for Genetic Medicine Research at Children's National Medical Center (CNMC) and …

Duchenne muscular dystrophy (DMD; dystrophin-deficiency) causes dilated cardiomyopathy
in the second decade of life in affected males. We studied the dystrophin-deficient mouse …

Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic
beats arising from the pulmonary veins and atrium, but the source and mechanism of these …

Prompt diagnosis of children with suggested cardiac disease in the acute care setting is critical
for initiation of life-saving therapy. We hypothesized that pediatric critical care physicians …