INTRODUCTION To date, 559 humans have been flown into space, but long-duration (>300
days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars …

A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty
liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is …

A major bottleneck for validation of new clinical diagnostics is the development of highly
sensitive and specific assays for quantifying proteins. We previously described a method, stable …

Advances in omics technologies now allow an unprecedented level of phenotyping for
human diseases, including obesity, in which individual responses to excess weight are …

Despite their potential to impact diagnosis and treatment of cancer, few protein biomarkers
are in clinical use. Biomarker discovery is plagued with difficulties ranging from technological (…

To investigate the biological processes that are altered in obese subjects, we generated cell-specific
integrated networks (INs) by merging genome-scale metabolic, transcriptional …

We performed integrative network analyses to identify targets that can be used for effectively
treating liver diseases with minimal side effects. We first generated co‐expression networks …

Multiple approaches for simplifying the serum proteome have been described. These
techniques are generally developed across different laboratories, samples, mass spectrometry …

Objectives Genetic or acquired defects in FOXP3 + regulatory T cells (Tregs) play a key role
in many immune‐mediated diseases including immune dysregulation polyendocrinopathy, …

Cells employ error-free or error-prone postreplication repair (PRR) processes to tolerate
DNA damage. Here, we present a genome-wide screen for sensitivity to 0.001% methyl …